Curriculum vitae

BOOKS AND REVIEW ARTICLES:

1. Kirsch WM, Schulz DW, Leitner JW: The quantitative histochemistry of the experimental glioblastoma: glycolysis and growth. Acta Histochem. 1967;28:51-85.

2. Kirsch WM, Grossi-Paoletti E, Paoletti P, Eds. The Experimental Biology of Brain Tumors. Springfield IL: Charles C Thomas Publisher; 1972.

PAPERS AND BOOK CHAPTERS:

1. Kirsch WM, Carlsson S, Hartmann A: A case of anomalous drainage of the superior vena cava into the left atrium. J Thorac Cardiovasc Surg. 1961;41:550-556.

2. Kirsch WM: Histochemical and quantitative analysis of alkaline phosphatase during the course of experimental intracranial neoplasia. Neurology. 1963;13:123-134.

3. Kirsch WM: Substrates of glycolysis in intracranial tumors during complete ischemia. Cancer Res. 1965;25:432-439.

4. Kirsch WM, Hodges FJ: An intramedullary epidermoid inclusion cyst of the thoracic cord associated with a previously repaired meningocele. J Neurosurg. 1966;24:1018-1020.

5. Kirsch WM, Leitner JW: Glycolytic metabolites and co-factors in human cerebral cortex and white matter during complete ischemia. Brain Res. 1967;4:358-368.

6. Kirsch WM, Leitner JW: A comparison of the anaerobic glycolysis of human brain and glioblastoma. J Neurosurg. 1967;27:45-51.

7. Kirsch WM, Leitner JW: An assay for organic phosphorus fractions in microgram quantities of tissue. Ann Biochem. 1967;21:39-45.

8. Kirsch WM: Quantitative changes in the phosphorus fractions of transplanted brain tumors during complete ischemic incubation. Experientia. 1967;23:586-588.

9. Kirsch WM, Leitner JW, Schulz DW: The effect of prolonged ischemia upon regional energy reserves in the experimental glioblastoma. Cancer Res. 1967;27:2212-2220.

10. Kirsch WM, Duncan B, Black FW, Stears JC: Laryngeal palsy in association with myelomeningocele, hydrocephalus and the Arnold-Chiari malformation. J Neurosurg. 1968;28:207-214.

11. Hsie AW, Rickenbert HW, Schulz DW, Kirsch WM: The steady-state concentration of glucose-6-phosphate, 6-phosphogluconate, and reduced NADPH in strains of E. coli sensitive and resistant to catabolite repression. J Bacteriol. 1969;98:1407-1408.

12. Kirsch WM, Newkirk JB, Predecki P: A new silicone rubber shunting device for the treatment of hydrocephalus. J Surg Res. 1969;1:199-203.

13. Black FO, Kirsch WM, Weaver M: Choristoma of the pharynx in a newborn. Laryngoscope. 1969;79:2068-2071.

14. Kirsch WM, Leitner JW: Comparison of anaerobic glycolysis of human brain and glioblastoma. Yearbook of Cancer. 1969:16-19.

15. Sussman KE, Alfrey A, Kirsch WM, Zweig P, Felig P, Messner F: Chronic lactic acidosis in an adult: A new syndrome associated with an altered redox state of certain NAD/NADH coupled reactions. Am J Med. 1970;48:104-112.

16. Kirsch WM, Newkirk JB, Predecki PK: Clinical experience with the Denver Shunt: A new silicone rubber shunting device for the treatment of hydrocephalus. J Neurosurg. 1970;32:258-264.

17. Kirsch WM, Stears JC: Case Report: Actinomycosis osteomyelitits of the skull and epidural space. J Neurosurg. 1970;33:347-351.

18. Kirsch WM: Pathophysiology of spina bifida. In: Proceedings Symposium on Spina Bifida, University of Colorado Medical Center; 1969 Nov:10-14.

19. Kirsch WM: Pathophysiology of hydrocephalus. In: Proceedings Symposium on Spina Bifida, University of Colorado Medical Center; 1969:93-103.

20. Kirsch WM, Newkirk JB, Predecki P: Polymers in neurosurgery: The development of a new silicone rubber shunting device for the treatment of hydrocephalus. In: Biomedical Materials, Polymer Conf. Series, U. Utah, College of Engineering; June 1970.

21. Kirsch WM, Leitner JW, Gainey M, Schulz DW, Lasher R, Nakane PK: Bulk isolation in non-aqueous media of nuclei from lyophilized cells. Science. 1970;168:1592-1595.

22. Hendee WR, Kirsch WM: Effects of ionizing radiation upon normal and neoplastic neural tissue. In: Kirsch, Paoletti and Paoletti, Eds. The Experimental Biology of Brain Tumors. Springfield IL: Charles C Thomas Publisher; 1972:400-518.

23. Kirsch WM, Schulz DW: Anaerobic energy metabolism of brain and derivative neoplasm. In: Kirsch, Paoletti and Paoletti, Eds. The Experimental Biology of Brain Tumors. Springfield IL: Charles C Thomas Publisher; 1972:275-298.

24. Kirsch WM, Schulz DW: The chemical induction of brain tumors with carcinogenic hydrocarbons and miscellaneous agents. In: Kirsch, Paoletti and Paoletti, Eds. The Experimental Biology of Brain Tumors. Springfield IL: Charles C Thomas Publisher; 1972:181-193.

25. Kirsch WM, Stears JC: Radiographic identification and surgical excision of an epidermoid tumor of the pineal gland: Case Report. J Neurosurg. 1970;33:708-713.

26. Kirsch WM, Schulz DW, Nakane PK, Lasher R, Yamamoto T: Isolation and characterization of glioblastoma nuclei and chromosomes in the lyophilized state. J Neurosurg. 1971;34:301-309.

27. Kirsch WM, Schulz DW: Regional bioenergetic events in the experimental glioblastoma. A quantitative histochemical study. J Neurosurg. 1971;34:448-451.

28. Lende R, Kirsch WM, Druckman R: Relief of facial pain after combined removal of precentral and postcentral cortex. J Neurosurg. 1971;34:537-543.

29. George RH, Sussman KE, Leitner JW, Kirsch WM: Inhibition of glucose and tolbutamide-induced insulin release by iodoacetate and antimycin A. Endocrinology. 1971;89:169-176.

30. Kirsch WM: Anaerobic energy metabolism of brain tumors. Prog Exp Tumor Res. 1972;17:163-191.

31. Kirsch WM, Schulz DW, Fuchs E, Nakane PK: The effect of ionizing radiation on nuclear energy transduction in normal and neoplastic glia: A quantitative chemical study. Acta Radiol. 1972;11:349-360.

32. Waddell WR, Bradshaw RA, Goldstein MN, Kirsch WM: Human nerve growth factor: Production in a patient with a liposarcoma. Lancet. 1972 Jun:1365-1367.

33. Kirsch WM: ACS Clinitape. Neuroanesthesia (Panel) Program Number C72-NS2. Cassette tape, American College of Surgeons Meeting. San Francisco; October 1972.

34. Kirsch WM: Book Review: Biochemistry and the Central Nervous System, by Henry McIlwain and H.S. Bachelard. J Neurosurg. 1973;38:532.

35. Van Buskirk JJ, Kirsch WM: Loss of hepatoma RNA during warfarin therapy. Biochem Biophys Res Comm. 1973;52:562-568.

36. Kirsch WM, Schulz DW, Van Buskirk JJ, Young HE: Effects of sodium warfarin and carcinostatic agents on malignant cells: A study of drug synergy. J Med. 1974;5:69-82.

37. Kirsch WM, Penn I, Stears JC: Neurosurgical complications associated with organ transplantation. In: Walker EA, Slade HW, Resnick BS, Eds. Neurosurgery Review, (cassette tape in the Professional Information Library, 130 Parkhouse, Dallas, Texas 75207), July 1974.

38. Ferguson JF, Kirsch WM: Case report: Epidural empyema following thoracic extradural block. J Neurosurg. 1974;41(6):762-763.

39. Kirsch WM: A new method of managing chronic pain. Medical Times. 1974 Nov;102:115-118.

40. Kirsch WM, Van Buskirk JJ, Schulz DW: Thoughts on the biology and therapy of malignant gliomas. In: Recent Results in Cancer Research, Gliomas. Berlin, Heidelberg, New York: Springer-Verlag; 1975;51:110-118.

41. Kirsch WM: Book Review: Acromegaly, by Jan Kinman. J Neurosurg. 1975;42:112-113.

42. Ignelzi RJ, Kirsch WM: Analysis of ventriculoperitoneal and ventriculoatrial shunts for hydrocephalus. J Neurosurg. 1975;42(6):679-682.

43. Tabuchi K, Kirsch WM: Immunocytochemical localization of S-100 protein in hamster cerebellum. Brain Res. 1975;92:175-180.

44. Kirsch WM, Ignelzi RJ: Cerebral edema: The role of astoglia. In: Controversies in Neurosurgery, Thomas Morley, Ed., W. B. Saunders Company, 1976:595-604.

45. Law JD, Lehman RAW, Kirsch WM, Ehni G: Abscess of the central ganglia. J Neurosurg. 1976;44(2):226-232.

46. Kirsch WM, Lewis JA, Simon RH: Experiences with electrical stimulation devices for the control of chronic pain. Med Instrumentation. 1975;9(5):217-220.

47. Tabuchi K, Lehman J, Kirsch WM: Immunocytochemical localization of simian virus 40 T-antigen with peroxidase labeled antibody fragments. J Virology. 1976;17(2):668-671.

48. Kirsch WM, Van Buskirk JJ, Schulz DW, Tabuchi K: The biologic basis of malignant brain tumor therapy. In: Advances in Neurology. Raven Press; 1976;15:301-313.

49. Tabuchi K, Kirsch WM, Nakane PK: The fine structural localization of S-100 protein in rodent cerebellum. J Neurol Sci. 1976;28:65-76.

50. Wilson B, Kirsch WM, et al.: Monitoring of visual function during parasellar surgery. Surg Neurol. 1976 Jun;5(6):323-329.

51. Tabuchi K, Kirsch WM, Van Buskirk JJ, Schulz DW: Immunocytochemical evidence for SV40-related tumor antigen in two human brain tumors of ependymal derivation. Acta Neurochirurgica. 1978;43:239-249.

52. Kirsch WM: Book Review: Brain Tumor Chemotherapy, by Derek Fewer, Charles B. Wilson ,Victor A. Levin.. JAMA. 1977 4/Apr;237:1494.

53. Tabuchi K, Nishimoto A, Kirsch WM, Van Buskirk JJ: Screening of human brain tumors for SV40-related T antigen. J Neurol Medico-Chirugica (Tokyo). 1977;17II(5):383-390.

54. Van Buskirk JJ, Kirsch WM: The occurrence of gammacarboxyglutamic acid in mammalian ribosomes. Biochem Biophys Res Comm. 1978;80(4):1033-1038.

55. Tabuchi K, Kirsch WM, Low M, Gaskin D, Van Buskirk JJ, Maa S: Screening of human brain tumors for SV40-related T antigen. Int J Cancer. 1978;21:12-17.

56. Tucker WS, Kirsch WM, Martinez-Hernandez A, Fink LM: In vitro plasminogen activator activity in human brain tumors. Cancer Res. 1978 Feb;8:297-302.

57. Law JD, Lehman RAW, Kirsch WM: Reoperation after lumbar intervertebral disc surgery. J Neurosurg. 1978;48:259-263.

58. Kirsch WM, Ferguson JF, Ignelzi RJ: Regional differences in arterial metabolic rates: Its significance in relation to cerebral vasospasm. In: J Cervos-Navarro, et al., Eds. Advances in Neurology, Vol. 20, Pathology of Cerebrospinal Microcirculation. New York: Raven Press; 1978 Jun:47-57.

59. Ignelzi RJ, Kirsch WM: Sodium sequestration in vertebrate glial nuclei implications in the pathogenesis of ischemic brain injury. In: J Cervos-Navarro, et al., Eds. Advances in Neurology, Vol. 20, Pathology of Cerebrospinal Microcirculation. New York: Raven Press; 1978 Jun:231-236.

60. Kirsch WM, Tucker WS, Tabuchi K, Fink LM, Van Buskirk JJ: The metabolism of the glioblastoma: Pathobiological correlates. In: Clinical Neurosurgery, Vol. 25, Chap. 20. Baltimore: Williams & Wilkins Co; 1978:310-325.

61. Coyer B, Pryor JR, Kirsch WM, Blount SG, Jr.: Left stellectomy in the long QT syndrome. Chest. 1978 Nov;74:584-586.

62. Van Buskirk JJ, Kirsch WM: Gamma carboxyglutamic acid in eukaryotic and prokaryotic ribosomes. Biochem Biophys Res Comm. 1978;82(4):1329-1331.

63. Tabuchi K, Kirsch WM: Detection of IgG on glioblastoma cell surface in vivo. Acta Neurochirurgica. 1978;43:93-100.

64. Jawadi HM, Kirsch WM, Lock JP, Betz G: Hydrocephalus and amenorrhea. Obstet Gynecol. 1979 Feb;53(2):263-266.

65. Batt J, Cox RL, Hoke CH, Kirsch WM, et al.: False positive gram stains due to non-viable organisms in sterile commercial transport medium-Colorado, Ohio. Morbidity Mortality Weekly Rep. 1978:27:23.

66. Kirsch WM: Head Injuries. In: Bernard Gardner, et al., Eds. Basic Surgery: A Symptom-Oriented Approach, Chap. 36. New York: Appleton-Century-Crofts; 1978:505-513.

67. Tabuchi K, Nishimoto A, Kirsch WM: Immunoelectronmicroscopic localization of S-100 protein in cultured rat glioma cells. Acta Neuropath (Berl.). 1978;44:159-162.

68. Handel N, Law J, Hoehn R, Kirsch WM: Monitoring visual evoked response during craniofacial surgery. In: Annals of Plastic Surgery, Vol. 2, No. 3. Boston: Little, Brown, & Co.; March 1979.

69. Kirsch WM, Van Buskirk JJ, Low M, Tabuchi K, Tucker WS, Fink LM: Examination of the ribosome as a control point for malignant glial tumors. In: P. Paoletti, M.D. Walker, G. Butti, and R. Knerich , Eds. Proceedings of the International Symposium on Multidisciplinary Aspects of Brain Tumor Therapy, Gardone Riviera, Italy, June 8-10, 1979. Baltimore: Elsevier/North Holland Press; 1979.

70. Van Buskirk JJ, Low M, Kirsch WM: Growth-related changes in the carboxylation of the E. coli ribosomes. Proc. Eighth Steenbock Symp. In: J.W. Suttie, Ed., Vitamin K Metabolism: Vitamin K-Dependent Proteins. Baltimore: University Park Press; 1979:274-278.

71. Low M, Van Buskirk JJ, Kirsch WM: Detection of gamma carboxyglutamic acid by dansylation. Proc. Eighth Steenbock Symp. In: J.W. Suttie, Ed., Vitamin K Metabolism: Vitamin K-Dependent Proteins. Baltimore: University Park Press; 1979:150-152.

72. Jafek BW, Krekorian EA, Kirsch WM, Wood RP: Juvenile nasopharyngeal angiofibrom: Management of intracranial extension. Head Neck Surg. 1979;2:119-128.

73. Kirsch WM, et al.: Intracranial tumors: Their pathophysiology, specific properties, and prospects for future control. In: Roger N. Rosenberg, MD, Ed., The Science and Practice of Clinical Medicine, Vol. 5 - Neurology. New York: Grune & Stratton, Inc.; 1980:319-369.

74. Kirsch WM, Vogel H: Gliomas. In: Ben Eiseman, Ed., Prognosis of Surgical Disease. Philadelphia: W.B. Saunders & Co.; 1980:24-25.

75. Law JD, Swett J, Kirsch WM: Retrospective analysis of 22 patients with chronic pain treated by peripheral nerve stimulation. J Neurosurg. 1980;52:482-485.

76. Tobuchi K, Nishimoto A, Kirsch WM: Localization of SV40 T-antigen in mitotic cells by an immunoperoxidase method. Experientia. 1980;36(9):1053-1054.

77. Christy RM, Barkley RM, Koch TH, Van Buskirk JJ, Kirsch WM: The new amino acid, $-carboxyaspartic acid (ASA). Laboratory synthesis and identification in the ribosomal proteins of E. coli and subsequent synthesis. J Am Chem Soc. 1981;103(13):3935-3937.

78. Koch TH, Christy MR, Barkley RM, Sluski R, Bohemier D, Van Buskirk JJ, Kirsch WM: $-Carboxyaspartic acid (ASA): Methods Enzymol. 1984;107:563-575.

79. Van Buskirk JJ, Kirsch WM, Kleyer DL, Barkley RM, Koch TH: Aminomalonic acid: Identification in E. coli and atherosclerotic plaque. Proc Natl Acad Sci. 1984 Feb;81(3):722-725.

80. Kanter K, Kanter M, Kirsch WM, Rosenberg G: Spontaneous posterior fossa subdural hematoma as a complication of anticoagulation. Neurosurg. 1984;15:241-242.

81. Zhu YH, Kirsch WM, Cushman R, Becker K, McCabe W, Kornfeld M, Saland L, Cooper VR: Comparison of suture and clip for microvascular anastomoses. Am Coll Surg, Surg Forum. 1985;36:492-495.

82. Bicknell JM, Kirsch WM, Seigel R, Orrison W: Atlanto-axial dislocation in acute rheumatic fever. Case report. J Neurosurg. 1987 Feb;66(2):286-289.

83. Sillerud LO, Kirsch CF, Pennino R, Miller G, Cappon J, Kornfeld M, Kirsch WM, Omer G: Monitoring of early wallerian degeneration in rat sciatic nerve using high field proton NMR spectroscopy. Am Coll Surg, Surg Forum. 1987;38:555-558.

84. Wheelan P, Kirsch WM, Koch T: Decarboxylation of peptide bound aminomalonic acid (AMA). J Org Chem. 1989;54:1364-1370.

85. Wheelan P, Kirsch WM, Koch T: Free radical carboxylation of peptide- and protein-bound glycine to form peptide- and protein-bound aminomalonic acid (AMA). J Org Chem. 1989;54:4360-4364.

86. Kirsch WM, Zhu YH: Intraoperative digital subtraction angiography for neurosurgery. West J of Med. 1990 Nov;153(5):547-548.

87. Waddell WR, Kirsch WM: Testolactone, sulindac, warfarin and vitamin K₁ for inoperable desmoid tumors. Am J Surg. 1991;161(4):416-421.

1. Kirsch WM: The Kirsch micro clip: Modeled after a soldier ant. Loma Linda University Scope. 1991;27(3):36-40.

89. LeGrand EK, Stoloff DR, Kirsch WM, Zhu Yh, Boukouvalas Z, Hardesty RA: Dilatation in anastomosed arteries can be an artifact of explantation. Microsurg. 1992;13(1):31-35.

90. Gaskill DM, Stewart SC, Kirsch WM, Zhu YH, Thompson K: Sutureless vasovasostomy: A new technique using experimental microclip in rat model. Urology. 1992;40(2):191-194.

91. Kirsch WM, Zhu YH, Gaskill DM, Stewart SC, Hardesty RA, Lyons T: Tissue reconstruction with non-penetrating arcuate-legged clips: Potential endoscopic applications. J Reproduct Med. 1992 Jul;37(7):581-586.

92. Kirsch WM, Zhu YH, Hardesty RA, Chapolini R: A new method for microvascular anastomosis: Report of experimental and clinical research. Am Surg. 1992 Dec;58(12):722-727.

93. Copley SD, Frank E, Kirsch WM, Koch T: Detection and possible origins of aminomalonic acid in protein hydrolysates. Anal Biochem. 1992 Feb;201(1):152-57.

94. Zhu YH, Kirsch WM: A new surgical technique for venous reconstruction: The nonpenetrating clip. In: Chang JB, Ed., Modern Vascular Surgery, Volume 5. New York: Springer-Verlag Inc.; 1992:425-463.

95. Kirsch WM: A new concept for wound approximation. The Circle of Care. 1992 Winter:6-7.

96. Kirsch WM, Zhu YH, Boukouvalas Z, Cushman R: Chapter 9. Instrumentation. In: Sun Lee, MD, Ed. Color Atlas of Microsurgery. St. Louis: IEA Publishers; 1993.

97. Kirsch WM, Zhu YH, Boukouvalas Z, Hardesty RA: Chapter 10: Microvascular anastomoses: Surgical technique. In: Sun Lee, MD, Ed. Color Atlas of Microsurgery. St. Louis: IEA Publishers; 1993.

98. Kirsch WM, Zhu YH, Boukouvalas Z, Hardesty RA, LeGrand E, Mann P: Chapter 11: Morphologic events during healing of microvascular anastomoses. In: Sun Lee, MD, Ed. Color Atlas of Microsurgery. St. Louis: IEA Publishers; 1993:89-101.

99. Kirsch WM, Zhu YH, Hardesty RA, Webster MHC, Boukouvalas Z, Furnas D: Chapter 12: The Non-penetrating arcuate-legged clip: clinical applications. In: Sun Lee, MD, Ed. Color Atlas of Microsurgery. St. Louis: IEA Publishers; 1993.

100. Kirsch WM, Zhu YH, Gaskill D, Stewart S, Hardesty RA, Lyons TL: Chapter 51: Tissue reconstruction with nonpenetrating arcuate-legged clips: Potential endoscopic applications. In: Dr. Robert B. Hunt, Ed. Endoscopy in Gynecology - Proceedings of the AAGL 20th Annual Meeting; 1993:321-326.

101. Kirsch WM, Zhu YH, Hardesty RA, Petti G, Furnas D: Non-penetrating clips successfully replacing sutures in "base of skull" surgery. J Skull Base Surg. 1993;3(4):171-181.

102. Kirsch WM, Zhu YH, Boukouvalas Z, Cushman R, Hardesty RA, Chrisler J: The anastomoses of small arteries and veins by clips: A description of instruments. In: Zhong-Gao Wang, MD, Ed. Vascular Surgery. Beijing: International Academic Publishers; 1993.

103. Oberg KC, Kirsch WM, Hardesty RA: Prospectives in cleft lip and palate repair. Clin Plast Surg. 1993; 20(4):815-821.

104. Zhu YH, Kirsch WM, Tredway D, Weber K, Norburg M, Oberg KC, Saukel GW, Seraj I, Chrisler J: Non-penetrating, arcuate-legged clip reconstruction of the rat uterine horn. J Am Assoc Gynecol Laparosc. 1994;1(4 Pt 1):395-400.

105. Tredway DR, Kirsch WM, Zhu YH, Weber K, Norburg M, Saukel GW, Seraj I: A new concept for anastomosis of the fallopian tube: tissue reconstruction with nonpenetrating, arcuate, legged clips in the rat model. Fertil Steril. 1994 Sep;62(3):624-629.

106. Zhu YH, Steckel R, Kirsch WM: Comparative evaluation of suture and nonpenetrating metal clips for vascular reconstruction. Am Coll Surg, Surg Forum. 1994;XLV:593-597.

107. Kirsch WM, Robles A, Mensink J, Zhu YH: Successful laparoscopic revision of distally obstructed ventriculo-peritoneal shunts. J Min Invas Ther. 1994;(3):261-263.

108. Evans ML, Oberg KC, Kirsch WM, Zhu YH, Hardesty RA: Intrauterine repair of cleft lip-like defects in lambs with a novel microclip. J Craniofacial Surg. 1995 Mar;6(2):126-132.

109. Oberg KC, Evans ML, Nguyen T, Peckham NH, Kirsch WM, Hardesty RA: Intrauterine repair of a surgical created cleft lip-like defects in mice (a lip incision model) utilizing a new microclip: A preamble to endoscopic intrauterine surgery. Cleft Palate-Craniofac J. 1995 Mar;32(2):129-137.

110. Robinson J, Oberg KC, Kirsch WM, Wood VE: Intrauterine and juxtanatal repair of syndactyly in fetal mice. J Hand Surg [Br]. 1995 Jun;20(3):319-326.

111. Oberg KC, Robles AE, Ducsay CA, Childers BJ, Gates DL, Kirsch WM, Hardesty RA: Endoscopic creation and repair of cleft lip-like defects in fetal lambs. Min Invas Ther. 1995;4(suppl 1)57:47.

112. Kihara SI, Nehlsen-Cannarelli S, Kirsch WM, Chase D, Garvin AJ: A comparative study of apoptosis and cell proliferation in infantile and adult fibrosarcomas. Am J of Clin Pathol. 1996;106(4):493-497.

113. Nataf P, Kirsch W, Hill AC, Anton T, Zhu YH, Ramadan R, Lima L, Pavie A, Cabrol C, Gandjbakhch I: Nonpenetrating clips for coronary anastomosis. Ann Thorac Surg. 1997;63:S135-7.

114. Kirsch WM, Zhu YH, Wahlstrom E, Wang, ZG, Hardesty R, Oberg K: Vascular reconstructions with nonpenetrating arcuate-legged clips. In: Yao, J S T, Pearce, WH, Eds. Techniques in Vascular and Endovascular Surgery. Appleton & Lange; 1998;6:67-89.

115. Oberg KC, Robles AE, Ducsay CA, Rasi CR, Rouse GA, Childers BJ, Evans ML, Kirsch WM, Hardesty RA: Endoscopic intrauterine surgery in primates: Overcoming technical obstacles. Surg Endosc. 1999 Apr;13(4):420-426.

116. Oberg KC, Robles AE, Ducsay CA, Childers BJ, Rasi CR, Gates GL, Kirsch WM, Hardesty RA: Endoscopic excision and repair of simulated bilateral cleft lips in fetal lambs. Plast Reconstr Surg. 1998 Jul;102(1):1-9.

117. Nataf P, Hinchliffe P, Menzo S, Simpson J, Kirsch WM, Zhu YH, Anton T: Facilitated vascular anastomoses: The one-shot device. Ann Thorac Surg. 1998 Sep;66(3):1041-1044.

118. Kirsch WM: Observations provide further evidence for the excellent morphologic quality of the clipped, non-penetrated arterial venous anastomoses. Invited Commentary on Izzat et al: Favorable scanning electron microscopy findings of stapled vein to carotid artery anastomosis. (On STS Website [ Ann Thorac Surg. Feb. 23, 1999.

119. Zhu YH, Kirsch WM, Wang ZG: The vascular closure system and its controlled, randomized clinical trials. In: Vascular Surgery. Proceedings of the Third Congress of the Asian Vascular Society, Zhong-Gao Wang, Ed., Beijing China; 1998, Vol. 2, 684-691.

120. Kirsch WM: Multimodality monitoring of the neurosurgical patient. In: Neurobase: Neurosurgical Edition, Sherman C. Stein, Ed., San Diego: Arbor Publishing; 4^th 1999 Edition.

121. Palm SJ, Kirsch WM, Zhu YH, Peckham N, Kihara S-I, Anton R, Anton T, Balzer K, Eickman T; Dural closure with non-penetrating clips prevent meningoneural adhesions: An experimental study in dogs; Neurosurg. 1999;45(4):875-882.

122. Wang X, Kirsch WM, Zhu YH, Fei C; Study on distribution of Ama in normal and tumorous tissue. Chinese J Exp & Clin Immunol. 1999 Nov;23:1-4.

SELECTED ABSTRACTS (1990-present):

1. Kirsch WM, Zhu YH, et al.: Arterial Reconstruction Utilizing Bovine Pericardial Prosthesis and Non-Penetrating Clips During the Course of Aneurysm Surgery. Neurosurgical Society of America, Pebble Beach, California, April 11, 1990.

2. Kirsch WM, Zhu YH, et al.: Arterial Reconstruction Utilizing Bovine Pericardial Prosthesis and Non-Penetrating Clips During the Course of Aneurysm Surgery. Tenth International Symposium, Microsurgery for Cerebrovascular Disease, San Francisco, California, July 14, 1990.

3. Kirsch WM, Zhu YH, et al.: Arterial Reconstruction Utilizing Bovine Pericardial Prosthesis and Non-Penetrating Clips During the Course of Aneurysm Surgery. American Academy of Neurological Surgery, Amelia Island, Florida, October 5, 1990.

4. Fowler SD, Kirsch WM, et al.: Aminomalonic Acid (AMA) Detected in Select Proteins from Granuloma Foam Cells by Gas Chromatography/Mass Spectrometry. 75th Annual Federation of American Societies for Experimental Biology Meeting, Atlanta, Georgia, April 21-25, 1991.

5. Kirsch WM, Zhu YH: New Method for Arterial Reconstruction During the Course of Aneurysm Surgery. Tenth International Symposium on Microvascular Surgery for Cerebral Ischemia, San Francisco, California, July 13-15, 1991.

6. Fowler SD, Kirsch WM, et al.: Monoclonal Antibody to Aminomalonic Acid (AMA) Epitope Reactive to Arterial and Granuloma Foam Cells. 75th Annual Federation of American Societies for Experimental Biology Meeting, Atlanta, Georgia, April 21-25, 1991.

7. Fowler SD, Kirsch WM, et al.: Localization of Aminomalonic Acid (AMA) Epitope in Granuloma Foam Cells. 75th Annual Federation of American Societies for Experimental Biology Meeting, Atlanta, Georgia, April 21-25, 1991.

8. Fowler SD, Kirsch WM, et al.: Isolation and Characterization of Aminomalonic Acid (AMA) Enriched Proteins from Granuloma Foam Cells. 75th Annual Federation of American Societies for Experimental Biology Meeting, Atlanta, Georgia, April 21-25, 1991.

9. Kirsch WM, Zhu YH: Venous Reconstruction with a Novel Non-Penetrating Clip: Endoscopic Extension of the Technology to Other Approximations. Research Society of Neurological Surgeons, Duke University Medical Center, Durham, North Carolina, May 4, 1991.

10. Cheng K, Kirsch WM, et al.: ¹³¹I Anti-AMA Monoclonal Antibody for Radioimaging of Atheromas. Seventh International Symposium of Radiopharmacology, Boston, Massachusetts, June 3-6, 1991.

11. Kirsch WM, Cheng K, et al.: Monoclonal Antibody to Aminomalonic Acid (AMA) Epitope Reactive to Arterial and Granuloma Foam Cells: A Probe for the Radioimaging of Atheromas. The American Academy of Neurological Surgery, Gleneden Beach, Oregon, September 24, 1991.

12. Hardesty RA, Kirsch WM, Webster M, Furnas D, Cushman, R: A New Microclip for Microvascular Anastomoses: Report of Experimental and Clinical Research. The Seventh Annual Meeting of the American Society For Reconstructive Microsurgery, Orlando, Florida, September 28-30, 1991.

13. Kirsch WM, Zhu YH: Use of A Microclip Via Minimally Invasive Surgery For Anastomosis and/or Closure of Tissue. World Congress of Gynecologic Endoscopy, The American Association of Gynecologic Laparoscopists 20th Annual Meeting, Las Vegas, Nevada, November 13-17, 1991.

14. Kirsch WM, Zhu YH, Hardesty RA: A New Method for Microvascular Anastomosis: Report of Experimental and Clinical Research. American College of Surgeons, Southern California Chapter, Indian Wells, California, January 17, 1992.

15. Kirsch C, Sillerud L, Zhu YH, Kirsch WM, Pennino R: Monitoring of Nerve Repair and Wallerian Degeneration by NMR Spectroscopy. Joint Section on Disorders of the Spine and Peripheral Nerves of the American Assocation of Neurological Surgeons and the Congress of Neurological Surgery, Miami, Florida, February 7, 1992.

16. Gulley J, Kirsch WM, Fowler S, Nehlsen-Cannarella S: Monoclonal Antibodies to Aminomalonic Acid-Containing Epitopes from a Human Prostate Coarcinoma Cell Line (DU-125). 76th Annual Federation of American Socieities for Experimental Biology Meeting, Anaheim, California, April 8, 1992.

17. Webster M, Kirsch WM: Clinical Experience with the "Kirsch" Microclip in Microvascular Anastomosis. European Association of Plastic Surgeons, Pisa, Rome, May 15, 1992.

18. Hardesty RA, Nguyen T, Oberg K, Kirsch WM: Intra-Uterine Cleft Lip Repari Using the Kirsch Micro-Clip. Tri-County Surgical Society, Loma Linda, California, May 21, 1992.

19. Boukouvalas Z, Kirsch WM, Zhu YH, Hardesty RA: A New Surgical Technique for Venous Reconstruction: The Non-Penetrating Clip. First Congress of the International Society for Experimental Microsurgery, Rome, Italy, August 24, 1992.

20. Zhu YH, Kirsch WM, Stewart SC, Gaskill DM: Non-Penetrating Clips Replacing Sutures: Endoscopic Applications. First Congress of the International Society for Experimental Microsurgery, Rome, Italy, August 24, 1992.

21. Kirsch WM, Zhu YH, Stewart SC, Gaskill DM: Non-Penetrating Clips Replacing Sutures. International Congress of Gynecologic Endoscopy, AAGL 21st Annual Meeting, Chicago, Illinois, September 23-27, 1992.

22. Kirsch WM, Zhu YH, Stewart SC, Gaskill DM: A New Technique for Microsurgical Anastomoses: Report of Experimental and Clinical Research. International Congress of Gynecologic Endoscopy, AAGL 21st Annual Meeting, Chicago, Illinois, September 23-27, 1992.

23. Kirsch WM, Zhu YH, Stewart SC, Gaskill DM: Non-Penetrating Clips Replacing Sutures. 6th International Conference, The Korean Vascular Surgery Society, Seoul, Korea, October 1-3, 1992.

24. Kirsch WM, Zhu YH: A New Surgical Technique for Venous Reconstruction: The Non-Penetrating Clip. 6th International Conference, The Korean Vascular Surgery Society, Seoul, Korea, October 1-3, 1992.

25. Kirsch WM, Zhu YH, Hardesty RA: A New Method for Microvascular Anastomosis: Report of Experimental and Clinical Research. 6th International Conference, The Korean Vascular Surgery Society, Seoul, Korea, October 1-3, 1992.

26. Gaskill DM, Stewart SC, Kirsch WM, Zhu YH: Sutureless Vasovasostomy: A New Technique Demonstrating an Experimental Microclip Using a Rat Model. 48th Annual Meeting of the American Fertility Society in New Orleans, Louisiana, November 4, 1992.

27. Evans M, Oberg K, Kirsch WM, Hardesty RA: Intrauterine Cleft Lip Repair. American College of Surgeons, Southern California Chapter, Santa Barbara, California, January 24, 1993.

28. Robinson J, Oberg K, Kirsch WM, Wood V: Intrauterine Repair of Syndactly. American College of Surgeons, Southern California Chapter, Santa Barbara, California, January 24, 1993.

29. Kirsch WM, Zhu YH, Hardesty RA, Petti G, Furnas D: Non-Penetrating Clips Successfully Replacing Sutures in "Base of Skull" Surgery. North American Skull Base Society Meeting, Scottsdale, Arizona, February 12-14, 1993.

30. Kirsch WM, Zhu YH: A New Surgical Technique for Venous Reconstruction: The Non-Penetrating Clip. North American Skull Base Society, Scottsdale, Arizona, February 12-14, 1993.

31. Oberg KC, Evans M, Nguyen T, Kirsch WM, Hardesty RA: Intrauterine Cleft Lip Repair in the Mouse: A Preamble to Endoscopic Intrauterine Surgery. American Cleft Palate-Craniofacial Association, Pittsburgh, Pennsylvania, April 21, 1993.

32. Kirsch WM, Zhu YH: The Non-Penetrating Clip. Research Society of Neurological Surgeons Conference, Mater Private Hospital, Dublin, Ireland, June 10, 1993.

33. Robinson, J, Oberg KC, Kirsch WM, Wood VE: Intrauterine Repair of Synactyly. The 48th Annual Meeting of the American Society for Surgery of the Hand, Kansas City, Missouri, September 29-October 2, 1993.

34. Tredway DR, Kirsch WM, Zhu YH: A New Concept for Endoscopic Reanastomoses of the Fallopian Tube. International Congress of Gynecologic Endoscopy, AAGL 22nd Annual Meeting, San Francisco, California, November 13, 1993.

35. Kirsch WM, Oberg K, Zhu YH, Hardesty RA, Wood V, Tredway D, Stewart S, Gaskill D: Non-Penetrating Clips Replacing Sutures: Gynecologic Applications. International Congress of Gynecologic Endoscopy, AAGL 22nd Annual Meeting, San Francisco, California, November 13, 1993.

36. Kirsch WM, Zhu YH, Hardesty RA, Petti G, Furnas D: Nonpenetrating Clips Successfully Replacing Sutures in Base of Skull Surgery. Skull Base Surg. 3(4):171-183, 1993.

1. Kirsch WM, Wahlstrom E, Raithel D, Buttner P, Katzman H, Zhu Y, Scott J, St John-Hammond PG. A Multi-Centered Controlled Clinical Trial Comparing Clips to Suture for Construction of Hemodialysis Vascular Access Sites. 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, September 15-18, 1996.
2. Kirsch WM, Zhu Y, Steckel R, O’Malley D, Oberg K, Hardesty R: Comparative Evaluation of Suture and Non-Penetrating Titanium Clips for Vascular Reconstruction. 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, September 15-18, 1996.
3. Palm S, Reiser K, Kirsch WM, Zhu Y, Peckham N, Nelsen-Cannarella S, Kihara S, Oberg K, Hardesty R: Arterial Collagen Bonding by Pressure: A New Paradigm in Wound Healing. 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, September 15-18, 1996.
4. Kirsch WM, Zhu Y, Wang Z, Balzer K, Raithel D, Wahlstrom E, Hill A, Webster M, Hardesty R, Oberg K, Kihara S: Complex Vascular Reconstructions Facilitated by Non-Penetrating Arcuate-Legged Clips. 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, September 15-18, 1996.

41. Kirsch WM, Hardesty RA: Frontal Cranial Bone Advancement: What Happens to the Dead Space? Kim DB, Anton T, Afifi G, Plastic Surgery Research Council Meeting, April, 1998.

42. Kirsch WM, Zhu YH: A Long-Term Follow-Up of Cerebrovascular Reconstructions with Vascular Closure System (VCS^‚) Clips. American Academy of Neurological Surgeons, Annual Meeting, Santa Barbara, California, November 4-8, 1998.

43. Chai YH, Kirsch WM, Anton T, Thorpe DL: Comparison of suture and non-penetrating vascular clip: J Investigative Med; 47(2)/92A/99.

44. Kirsch WM, Johna S, Robles A: Laparoscopic Assisted Lumoperitoneal Shunting: Description of a New Surgical Procedure and Application to Clinical Problems, Neurosurgical Society of America, 53^rd Annual Meeting Durango, CO, June 4-7, 2000.

INVITED LECTURES, VISITING PROFESSORSHIPS, AND PAPERS PRESENTED AT MEETINGS (1969 to present): TOTAL: 183

1. Boston Surgical Society, Harvard Club, "Treatment of Cancer with Warfarin," May 1969, Invited.

2. Neuroscience Symposium, Washington University School of Medicine, St. Louis, Missouri, Invited, May 1970.

3. Biomedical Materials Conference, University of Utah Medical School, Salt Lake City, Utah, Invited, June 1970.

4. Chairman, Radiotherapy Session, Neuroradiology Congress, Gotenberg, Sweden, Invited, August 1970.

5. Institute of Medical Genetics, Oslo, Norway, "Isolation of Non-Aqueous Nuclei," Invited, August 1970.

6. Pasteur Institute, Department of Molecular Biology, "Isolation of Non-Aqueous Nuclei," Invited, September 1970.

1. International Neuropathology Congress, Paris, France, "Histochemistry of Brain Tumors," Invited, August 1970.

8. Ohio State University Centennial Celebration, Ohio State University Medical School, Neurosurgery Department, Columbus, Ohio, Invited, October 1970.

9. American College of Surgeons, Chicago, Illinois, Chairman, Fundamental Forum Session on Neurosurgery, Invited, October 1970.

10. Chairman of Neurosurgical Session, Association of Academic Surgeons, Denver, Colorado, Invited, November 1970.

11. Visiting Professor, Northwestern University School of Medicine, Section on Neurosurgery, Chicago, Illinois, November 1970.

12. Western Surgical Association, Colorado Springs, Colorado, Invited, November 1970.

13. Chicago Wesley Memorial Hospital, Chicago, Illinois, Invited, December 1970.

14. National Cancer Institute, Basic Science Seminar, Bethesda, Maryland, "Isolation and Characterization of Brain Tumor Nuclei in the Lyophilized State," Invited, January 1971.

15. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, Invited, February 1971.

16. American Association of Neurological Surgeons, Houston, Texas, "Combination Drug and Irradiation Therapy for Surgically Incurable Tumors of the Neuraxis," April 1971.

17. Visiting Professor, Max Planck Institute for Brain Research, Cologne, West Germany, two lectures on brain tumors, Invited, April 1971.

18. Observation to the Pathogenesis of Cerebral Edema - Academy Award for 1971.

19. Department of Neurosciences, University of California, San Diego, California, "The Biology of Gliomas," November 1971.

20. Johns Hopkins Hospital, Baltimore, Maryland, guest lecturer at the Neurology- Neurosurgery Science Seminar, December 1971.

21. Science Writers' Seminar, American Cancer Society, Clearwater Beach, Florida, Invited Participant, March 1972.

22. American Association of Neurological Surgeons, Boston, Massachusetts, "A Histochemical Examination of Pituitary Adenomas with Enzyme-Labeled Antibodies," April 1972.

23. Visiting Professor, Symposium on Neurosurgery, Free University of Berlin, Berlin, Germany, "Chemotherapy of Brain Tumors: The Biologic Basis" keynote speaker, May 1972.

24. Society of Neurological Surgeons, New Haven, Connecticut, "A Histochemical Examination of Pituitary Adenomas," May 1972.

25. Neurosurgical Clinic, Karolinska, Stockholm, Sweden, Invited Lecturer, "Chemotherapy of Brain Tumors," May 1972.

26. Second International Meeting of the International Society of Neurochemistry, Milano, Italy, Moderator and Panelist, "Biochemistry of Brain Tumors".

27. 69th Annual Meeting, Wyoming State Medical Society, Moran, Wyoming, Chairman, Scientific Sessions on "Proper Management and Recognition of Neurosurgical Problems Related to Head and Neck Trauma," and "Recognition and Management of Cerebral Tumors in General," Invited, August 1972.

28. American Academy of Neurological Surgery, Society of British Neurological Surgeons, Oxford, England, "Combination Drug and Irradiation Therapy for Surgically Incurable Tumors of the Neuraxis," September 1972.

29. Congress of Neurological Surgeons, Denver, Colorado, Invited Speaker, October 1972.

30. Western Neurosurgical Society, Tucson, Arizona, co-author of award-winning paper, "Sodium Compartmentalization in Vertebrate Brain Nuclei and the Biological Implications of this Discovery in the Human," October 1972.

31. American College of Surgeons, San Francisco, California, Moderator of Panel, "Neuroanesthesia," Invited, October 1972.

32. St. Louis Neurological and Neurosurgical Society, St. Louis, Missouri, "Combination Drug and Irradiation Therapy for Surgically Incurable Tumors of the Neuraxis," November 1972.

33. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, "Anti-Coagulants and Cancer," December 1972.

34. Treatment of Cancer Symposium, Philadelphia, film and lecture, "Combination Drug and Irradiation Therapy for Surgically Incurable Tumors of the Neuraxis," December 1972.

35. Institute of Medical Science, University of Toronto, Toronto, Ontario, Workshop on Brain Tumors; special lecture, "The Biology of Gliomas," February 1973.

36. Visiting Professor, Southwestern Medical School, Division of Neurosurgery, Dallas, Texas, "Combination Drug and Irradiation Therapy for Surgically Incurable Tumors of the Neuraxis," March 1973.

37. American Association of Neurological Surgeons, Los Angeles, California, "Synchronization of Glioblastoma Cells In Vitro by Sodium Warfarin: Therapeutic Implications," April 1973.

38. Neurosurgical Society of America, Bermuda, "Neurosurgical Complications Associated with Organ Transplantation," June 1973.

39. Harvard Medical School, Department of Neurosurgery, Boston, Massachusetts, Beth Israel Hospital, "Neurosurgical Complications Associated with Organ Transplantation," Invited, June, 1973.

40. Visiting Professor, University of Hokkaido School of Medicine, Sapporo, Japan, special lecture on "The Biology of Gliomas," Invited, October 1973.

41. Visiting Professor, Okayama University School of Medicine, Okayama, Japan, special lecture on "Chemotherapy of Brain Tumors," Invited, awarded Silver Medal, October 1973.

42. International Congress of Neurological Surgery, Tokyo, Japan, "A Histochemical Examination of Pituitary Adenomas with Enzyme-Labeled Antibodies," October 1973.

43. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, "Anticoagulation in the Treatment of Cancer," Invited Participant, November 1973.

44. American Academy of Neurological Surgeons, Pasadena, California, "Neurosurgical Complications Associated with Organ Transplantation," November 1973.

45. Research Society of Neurological Surgeons, Richmond, Virginia, "Thoughts on the Biology and Therapy of Brain Tumors," Invited by University of Virginia Cancer Research Center, March 1974.

46. American Association of Neurological Surgeons, St. Louis, Missouri, Special Symposium: The Biology of Gliomas, Invited, April 1974.

47. Visiting Professor, Bowman Gray School of Medicine, Winston-Salem, North Carolina, Invited, May 1974.

48. Symposium on Cerebral Gliomas, University of Chicago, "Thoughts on the Biology and Therapy of Malignant Gliomas," May 1974.

49. Guest Speaker, The Upjohn Company, Kalamazoo, Michigan, "Chemotherapy of Brain Tumors," Invited, May 1974.

50. Neurosurgical Society of America, Key Biscayne, Florida, "Management of Metastatic Tumors to the Central Nervous System," May 1974.

51. Guest Speaker, Congress of Neurological Surgeons, "Transsphenoidal Hypophysectomy," Vancouver, British Columbia, September 1974.

52. American College of Surgeons, Miami, Florida, "Pharmacokinetic Basis of Brain Tumor Chemotherapy," October 1974.

53. American Academy of Neurological Surgery, Bermuda, "Six Years of Experience with Chemotherapy for Malignant Tumors of the Neuraxis," November 1974.

54. Hand Society, Denver, Colorado, "Management of Peripheral Nerve Injuries to the Hand," Invited, January 1975.

55. 2nd Annual Barrow Neurological Institute Symposium, Phoenix, Arizona, "Biologic Basis of Malignant Brain Tumor Therapy," Invited, January 1975.

56. Pan Pacific Surgical Association, Honolulu, Hawaii, Invited Lecturer for two topics: "Brain Tumor Therapy," and "Advances in Management of Hydrocephalus," February 1975.

57. Southern Research Institute, Birmingham, Alabama, Invited Lecturer, "Brain Tumor Chemotherapy," February 1975.

58. Neurosurgical Society of America, Rancho Bernardo, California, "VER Monitoring of Visual Function During Parasellar Surgery," March 1975.

59. 25th Western Institute on Epilepsy, "New Concepts in Treatment and Rehabilitation in Epilepsy," Denver, Colorado, Invited, March 1975.

60. American Association of Neurological Surgeons, Miami, Florida, "Identification of a Unique Particle from Ewing's Sarcoma Involving the Cranial Vault," "Pyogenic Abscess of the Basal Ganglia," and "VER Monitoring of Visual Function During Parasellar Surgery," April 1975.

61. Visiting Professor, University of Kansas Medical Center, Invited Lecturer for two topics, "Biologic Basis of Brain Tumor Therapy," and "The Management of Secreting Pituitary Tumors," Kansas City, Kansas, May 1975.

62. Visiting Professor, Neurosurgical Service, University of California, San Francisco, California, Invited, October 1975.

63. Guest Lecturer, New York University Post Graduate Conference, New York, New York, "Brain Tumor Management," October 1975.

64. Invited Lecturer, Cook County Graduate School of Medicine, "Tumor Chemistry, Immunology, and Kinetics," February 1976.

65. Guest Lecturer, Free University of Berlin, Germany, "Immunocyotochemistry: Implications for Advances in the Neurosciences," February 1976.

66. Neurosurgical Society of America, Marco Island, Florida, "Advances in the Biology of Human Brain Tumors," and moderated discussion of brain tumors, March 1976.

67. American Association of Neurological Surgeons, San Francisco, California, "Detection of IgG in Glioblastoma Cells," April 1976.

68. Thirteenth Meeting of the Rocky Mountain Bioengineering Symposium, "Minicomputer Detection of Pain," May 1976.

69. Visiting Professor, Neurosurgical Service, University of Southern California, August 22-25, 1976.

70. Western Neurosurgical Society, Reno, Nevada, "Screening Human Brain Tumors for SV40-Related T-Antigen," September 26-29, 1976.

71. Invited Lecturer, Cook County Graduate School of Medicine, Chicago, Illinois, "Tumor Chemistry - Immunology - Kinetics," February 1977.

72. Visiting Professor, Rockefeller University, New York, Laboratory of Dr. Elaine Diakumakos, June 22-July 8, 1977.

73. Congress of Neurological Surgeons, San Francisco, California, "Metabolism of Brain Tumors," and "Central Pain," Invited, October 9-14, 1977.

74. American Academy of Neurological Surgery, Kamuela, Hawaii, "The Effect of Left Stellate Ganglionectomy upon Certain Cardiac Arrhythmias," November 2-5, 1977.

75. Visiting Professor, Neurosurgery Service, Mt. Sinai Medical School, New York, December 15-20, 1977.

76. Cook County Graduate School of Medicine, "Brain Tumors," Invited Speaker, February 8-11, 1978.

77. American Association of Neurological Surgeons, Invited Panelist. "Firing Line Panel of Experts," April 25-27, 1978.

78. Research Society of Neurological Surgeons, Columbia University School of Medicine, "GLA in Ribosomal Proteins," June 1-3, 1978.

79. Visiting Professor, Division of Radiation Oncology, Oncology Center, The Johns Hopkins Hospital, September 7-8, 1978.

80. Visiting Professor, Neurosurgery Service, Bethesda Naval Hospital, Bethesda, Maryland, December 14-16, 1978.

81. Cook County Graduate School of Medicine, Invited Speaker. "Brain Tumors: Immunology, Biochemistry, Kinetics," February 1979.

82. Invited Speaker, Washington Academy of Neurosurgery, Washington, D.C., December 12, 1978.

83. Program Chairman, Neurosurgical Society of America, 32nd Annual Meeting, The Greenbrier, White Sulphur Springs, West Virginia, May 23-27, 1979.

84. Visiting Professor, Medical College of Virginia, Neurosurgery Service, May 1979.

85. International Symposium on the Biology and Therapy of Brain Tumors, Invited Participant, Lake Garda, Italy, June 8-10, 1979.

86. Frie University, West Berlin/Max Planck Institute for Molecular Genetics. Invited Speaker, "GLA in Ribosomal Proteins," June 1-3, 1979.

87. American College of Surgeons, 65th Clinical Congress, Moderator of Panel, "What's New in the Laboratory That Can be Applied to Clinical Neurosurgery," Chicago, Illinois, October 21-26, 1979.

88. Visiting Professor, University of New York, Roswell Park, Buffalo, New York, January 1980.

89. Cook County Graduate School of Medicine, Review Course in Neurological Surgery, Invited Speaker. "Brain Tumors: Immunology, Biochemistry, Kinetics," February 1980.

90. Visiting Professor, University of Chicago Hospitals, Chicago, Illinois, February 1980.

91. Visiting Professor, Loyola University School of Medicine, Division of Neurosurgery, February 1980.

92. Cook County Graduate School of Medicine, Review Course in Neurological Surgery, Invited Speaker, "Brain Tumors: Immunology, Biochemistry, Kinetics," February 1981.

93. American Association of Neurological Surgeons (Cushing), Invited Panelist. "Breakfast Seminar, #56 - Firing Line," "The Ribosome as a Therapeutic Control Point for Malignant Tumors Involving the Neuraxis," April 5-9, 1981.

94. Cook County Graduate School of Medicine, Review Course in Neurological Surgery, Invited Speaker, "Brain Tumors: Immunology, Biochemistry, Kinetics," February 1982.

95. Neurosurgical Society of America, Key West, Florida, "Carboxylated Amino Acids in Atheromatous Plaque: A Clue to Pathogenesis and Therapy," 8-11, 1983.

96. American Society of Biological Chemists, San Francisco, California, "Identification of Aminomalonic Acid in Nature," Invited, June 5-9, 1983.

1. Cook County Graduate School of Medicine, Review Course in Neurological Surgery, Invited Speaker, "Brain Tumors: Immunology, Biochemistry, Kinetics," February 1983.

98. Neurosurgical Society of America, San Diego, California, "A Surgical Microclip and Suction Applicator for Microsurgical Anastomosis," May 13-16, 1984.

99. Fourth International Symposium on Organic Free Radicals, St. Andrews, Scotland, "A Free Radical Model for the Development of Atherosclerosis," July 1984.

100. Western Neurosurgical Society, Colorado Springs, Colorado, "A New Microvascular Clip for Small Vessel Anastomosis," and "Aminomalonic Acid, Atherosclerosis and Aging," September 9-12, 1984.

101. Conducted research seminar at Columbia University, "Recent Studies on the Calcium Binding Properties of Aminomalonic Acid (Ama) Residues in Proteins," October 29, 1984.

102. American College of Surgeons, Chicago, Illinois, "Comparison of Suture and Clip for Microvascular Anastomosis," October 13-18, 1985.

103. American Academy of Neurological Surgery, Houston, Texas, "Comparison of Suture and Clip for Microvascular Anastomosis," October 27-30, 1985.

104. American Society for Reconstructive Microsurgery, New Orleans, Louisiana, "Comparison of Suture and Clip for Microvascular Anastomosis," February 14-15, 1986.

105. The Western Neurosurgical Society, Maui, Hawaii, "Microflange Approximation of the Microvasculature," September 28-October 1, 1986.

106. American Society of Neuroimaging, Tampa, Florida, "Measurement of Flow Rates in Small Diameter Vessels," February 28-March 3, 1987.

107. Federation of Western Societies of Neurological Science, San Diego, California, "Comparison of Suture and Clip for Microvascular Anastomosis," March 29-April 1, 1987.

108. American Association of Neurological Surgeons, Dallas, Texas, "Comparison of Suture and Clip for Microvascular Anastomoses," May 3-7, 1987.

109. Neurosurgical Society of America, Gleneden Beach, Oregon, "The Biology of Endothelial Repair with Microflanged Arterial Approximation," May 10-13, 1987.

110. American Academy of Neurological Surgery, San Antonio, Texas, "Vertebral Artery Aneurysms," October 7-8, 1987.

111. Department of Plastic and Reconstructive Surgery, University of California at Irvine, Irvine, California, "New Procedures for Venous Hypertension Based on the Microclip including Free Flap Transfers," January 8, 1990.

112. St. Thomas's Hospital Surgery Department, London, England, "New Concept and New Device for Vessel Anastomosis, January 24, 1990.

113. British Microsurgical Society Annual Meeting, Glasgow, Scotland, "New Concept for Microvascular Anastomosis," January 25 & 26, 1990.

114. Plastic Surgery Research Council, Washington, D.C., "A New Microclip for Microvascular Anastomosis: Report of Experimental and Clinical Research," April 18-21, 1990.

115. Tenth International Symposium on Microvascular Surgery for Cerebral Ischemia, San Francisco, California, July 14, 1990.

116. Focused Giving Science Symposium, Johnson & Johnson, New Bruswick, New Jersey, "Studies on Atherosclerosis," November 28, 1990.

117. New York University Medical Center, U.N. Scientific Delegation for People's Republic of China, Microvascular Surgical Demonstration, New York, New York, December 1, 1990.

118. University of California at Los Angeles, Microvascular Surgical Demonstration, Los Angeles, California, December 6, 1990.

119. Anfui Provincial Hospital, "New Approach for Bypass Surgery," People's Republic of China, March 25, 1991.

120. Beijing Ji Shi Tan Hospital, Beijing Institute of Traumatology & Orthopaedics, "New Method for Blood Vessel Reconstruction," People's Republic of China, April 3, 1991.

121. Cedars-Sinai Medical Center, "Venous Reconstruction with a Novel Penetration Clip," Los Angeles, California, April 12, 1991.

122. Kaiser Permanente Medical Center, "Head and Spine Trauma," Fontana, California, April 26, 1991.

123. Research Society of Neurological Surgeons, Duke University Medical Center, "Venous Reconstruction with a Novel Non-Penetrating Clip: Endoscopic Extension of the Technology to Other Approximations," Durham, North Carolina, May 4, 1991.

124. Cedars-Sinai Medical Center, Microvascular Surgical Demonstration, Los Angeles, California, May 9, 1991.

125. Seventh International Symposium of Radiopharmacology, "¹³¹I Anti-AMA Monoclonal Antibody for Radioimaging of Atheromas," Boston, Massachusetts, June 3-6, 1991.

126. University of Colorado Chemistry & Biochemistry Department, "Chemical and Biological Properties of Aminomalonic Acid (Ama) and Protein Bound Ama," Boulder, Colorado, September 15, 1991.

127. Loma Linda University Medical Center Biochemistry Department, "Percarboxylations and Postranslational Protein Modifications," Loma Linda, California, November 25, 1991.

128. Cabot Medical Corporation, Microvascular Surgical Demonstration, Langhorne, Pennsylvania, December 3, 1991.

129. United States Surgical Corporation, Microvascular Surgical Demonstration, Norwalk, Connecticut, December 4, 1991.

130. Davis & Geck, Microvascular Surgical Demonstration, Danbury, Connecticut, December 5-6, 1991.

131. University of Colorado Chemistry & Biochemistry Department, "Chemical and Biological Properties of Aminomalonic Acid (Ama) and Protein Bound Ama," Boulder, Colorado, February 15, 1992.

132. Microsurgical Replantation Transplantation Department, Microvascular Surgical Demonstration, San Francisco, California, April 15, 1992.

133. Shanghai 2nd Medical University, Ranji Hospital, "New Surgical Trade: Minimal Invasive Surgery," Shanghai, Peoples’ Republic of China, May 11, 1992.

134. University of Louisville Surgery and Ob/Gyn Departments, Urology Division, "A New Method for Microvascular Anastamosis," Louisville, Kentucky, May 19, 1992.

135. NORINCO(G) Corporation, "New Surgical Trade: Minimal Invasive Surgery," Shanghai, Peoples’ Republic of China, May 22, 1992.

136. Shanghai 2nd Medical University, Chinese Academy of Science, "New Surgical Trade: Minimal Invasive Therapy," Shanghai, Peoples’ Republic of China, May 27, 1992.

137. United States Surgical Corporation, Microvascular Surgical Demonstration, Norwalk, Connecticut, June 18, 1992.

138. EBI Special Spine Surgeon Forum, Consultant, New York, New York, June 19, 1992.

139. Visiting Professor, University of Thessalonika School of Medicine, Thessalonika, Greece, August 1992.

140. First Congress of the International Society for Experimental Microsurgery, "New Microsurgical Stapler," Rome, Italy, August 24, 1992, Invited speaker.

141. 6th International Conference, The Korean Vascular Surgery Society, "Non-Penetrating Clip," Seoul, Korea, October 1-3, 1992, Invited speaker.

142. Invited Speaker, Canniesburn Hospital, "The Non-Penetrating Clip, Glasgow, Scotland, June 14, 1993.

143. Invited Speaker, The Institute of Experimental Clinical Research, "The Non-Penetrating Clip," Aarhus, Denmark, June 21, 1993.

144. Invited Speaker, Kirsch WM, Zhu YH. Harvard Medical School, "Vascular Reconstruction with Non-Penetrating Arcuate-Legged Clips: A Comparative Study," Progress in Angioscopy: Endovascular Grafting & Interventional Techniques, 1995.

145. Two Presentations at the 22nd World Congress of the International Society for Cardiovascular Surgery, Sept. 10-15, 1995.

146. Poster Presentation, American College of Surgeons, "Collagen Binding by Pressure: A New Paradigm in Wound Healing," October 1995.

147. Invited Speaker, Saitama Medical University, Yamaguchi University, Kyushu University, " Clinical Applications of the VCS Clip," Feb.7-13, 1996.

148. Invited Speaker, Stanford University Medical School, Endovascular International Techniques "Hands On" Workshop. April 11-12, 1996.

149. Presentation at 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, A Multi-Centered Controlled Clinical Trial Comparing Clips to Suture for Construction of Hemodialysis Vascular Access Sites, September 15-18, 1996.

150. Presentation at 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, Comparative Evaluation of Suture and Non-Penetrating Titanium Clips for Vascular Reconstruction, September 15-18, 1996.

151.Presentation at 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, Arterial Collagen Bonding by Pressure: A New Paradigm in Wound Healing, September 15-18, 1996

152. Presentation at 45th International Congress of the European Society for Cardiovascular Surgery, Venice, Italy, Complex Vascular Reconstructions Facilitated by Non-Penetrating Arcuate-Legged Clips,September 15-18, 1996.

153. Invited Speaker, American College of Surgeons, San Francisco, CA, Moderated live from Loma Linda University Medical Center via closed-captioned satellite of surgical procedure on "AV Fistula using VCS* Vascular Clip System," October 8, 1996.

154. Invited Speaker, University of California, Los Angeles, Los Angeles, CA, "Vascular Clips vs. Suturing Vascular Anastomosis for Carotid Endarterectomy," November 4, 1996.

155. Invited Speaker, Harvard Medical School, "Vascular Reconstruction with Non-Penetrating Arcuate-legged Clips Reduces Intimal Hyperplasia: Endovascular Surgery and Interventional Techniques," 1996.

156. Invited Speaker, Albert Einstein College of Medicine, New York, "Experimental Basis For Clip Vascular Anastomoses: Why They Might Be Superior To Suture Anastomoses: Current Critical Problems, New Horizons and Techniques in Vascular and Endovascular Surgery," November 21-24, 1996.

157. Invited Speaker, University of Pennsylvania School of Medicine, Philadelphia, PA, Vascular Conference, "Vascular Reconstructions with the VCS Clip," March 17, 1997.

158. Invited Speaker, University of California, Irvine, "Collagen Healing by Compression: A New Paradigm in Wound Healing," April 30, 1997.

159. Invited Speaker, Allegheny General Hospital, Pittsburgh, PA, Vascular Surgical Conference, "Use of Non-Penetrating Clips in Neurosurgical Procedures," May 19, 1997.

160. Invited Speaker, University of Pittsburgh, Pittsburgh, PA, Transplantation Conference. (Dr. Thomas Starzl), "Use of Non-Penetrating Clips for Transplantation Surgery," May 19, 1997.

161. Invited Speaker, University of Pittsburgh, Pittsburgh, PA, Vascular Surgical Conference. "The Use of Non-Penetrating Clips for Vascular Reconstructions," May 19, 1997.

162. Invited Speaker, World Congress of Minimal Invasive Surgery, Paris, France, "Facilitated End-to-Side Vascular Anastomosis with the VCS Clip Applier," May 29, 1997.

163. Meeting of the American Academy of Neurological Surgery and the Canadian Neurosurgical Society, 59^th Annual Meeting, Banff, Alberta, Canada,"Vascular Reconstructions are Facilitated by Non-Penetrating Arcuate-Legged Clips," September 10-13, 1997.

164. Invited Speaker, Montefiore Medical Center, 24^th Annual Symposium on Critical Problems, New Horizons and Techniques in Vascular and Endovascular Surgery,, New York City. "Facilitated Vascular Anastomoses: The Non-Penetrating Arcuate-Legged Clip," November 20-23, 1997.

165. Harvard Medical School, Department of Continuing Medical Education, Progress in Angioscopy, Endovascular Surgery & Interventional Techniques 1997,Boston, MA. Advances in the Management and Imaging of Occlusive Vascular Disease. "New Cerebrovascular Surgery Applications of the Non-Penetrating Arcuate-Legged Clips," December 8, 1997.

166. Invited Speaker, Northwestern University Medical Center, Vascular Meeting, December 1997.

167. Invited Speaker, University of Washington, Department of Vascular Surgery,, Seattle, WA. "Vessel Anastomoses and the VCS^® Clip."January 29, 1998.

168. Invited Speaker, Allegheny General Hospital, Joint Latin American/North American Cerebrovascular Skull Base Workshop, "Vascular Reconstruction and Bypass," March 17, 1998.

169. Invited Speaker, The United States Surgical Corporation, Train the Trainers, Miami, FL, April 1 & 2, 1998.

170. Invited Speaker, Vascular Trauma Course, David Grant Medical Center, Uniformed Services University of the Health Sciences, "Vascular Closure Staples (VCS^®Clips)," April 15, 1998.

171. Invited Speaker,1998 American Association of Neurological Surgeons Annual Meeting,, Philadelphia, PA. Poster -- "Facilitated Vascular Anastomosis (The ‘Single Shot’ System)," April 25-30, 1998.

172. Daniel B. Kim, Toomas Anton, Ghada Afifi, Wolff Kirsch, Robert A. Hardesty. "Frontal Cranial Bone Advancement: What Happens to the Dead Space?" Presented at the Plastic Surgery Research Council Meeting April 1998 and Presented at the California Society of Plastic Surgery Meeting May 1998, Won best resident scientific presentation.

173. Invited Speaker, Harvard Medical School, Department of Continuing Education, The VCS clip for vascular reconstruction, Boston, MA, July 13, 1998.

174. Invited Speaker, 25^th Annual Symposium on Current Critical Problems, New Horizons and Techniques in Vascular and Endovascular Surgery. "Facilitated Vascular Anastomoses: The Non-Penetrating Arcuate Legged Clip. And What’s New in Vascular Clipping: The One-Shot Device and Effects of Clipping on Intimal Hyperplasia." Montefiore Medical Center, New York City, November 19-22, 1998.

175. Invited Speaker, Harvard Medical School, Department of Continuing Education. Progress in Angioscopy 1998: Minimally Invasive and Endovascular Surgery. Non-penetrant VCS Clip: An Improved Alternative to the Sutured Anastomosis. Boston, MA, December 6, 7 and 8, 1998.

176. Invited Speaker, Annual Scientific Meeting, American College of Surgeons, Southern California Chapter, "A New System for Cerebrovascular Reconstructions: Non-penetrating, Arcuate-Legged Clips," Santa Barbara, CA January 24, 1999.

177. Invited Speaker, 52^nd Annual Meeting of The Neurosurgical Society of America, "A Four-Year Experience with Non-Penetrating Arcuate-Legged Clips for Cerebrovascular Reconstructions," Scottsdale, AZ, March 28-31, 1999.

178. Invited Speaker, Medical College of Virginia, Virginia Commonwealth University, "Long-term follow-up of cerebrovascular reconstruction with vascular closure clips," Richmond, VA, April 24, 1999.

179. Invited Speaker, Third Congress of the International Society for Neurosurgical Technology and Instrument Invention, "The nonpenetrating arcuate-legged clip: A new paradigm for vascular reconstruction," Las Vegas, NV, April 30, 1999.

180. Invited Speaker, Davies Medical Center, "Microvascular reconstruction using the VCS clip," San Francisco, CA, July 23, 1999.

181. Invited Speaker, UCLA Medical Center, Liver Surgery Department, "What’s new in the use of vascular clips, what are their assets, liabilities and pitfalls," Los Angeles, CA, September 14, 1999.

182. Invited Speaker, Annual Clinical Assembly of Osteopathic Specialists (ACA), "Vascular anastomosis performed with a non-penetrating clip," Seattle, WA, October 2, 1999.

183. Invited Speaker, 26th Annual Symposium on Current Critical Problems, New Horizons and Techniques in Vascular and Endovascular Surgery. "What’s new in the use of vascular clips, what are their assets, liabilities and pitfalls," Montefiore Medical Center, New York City, November 20, 1999.

184. Invited Speaker, 53^rd Annual Meeting of The Neurosurgical Society of America. "Laparoscopic assisted lumboperitoneal shunting: Description of a new surgical procedure and application to clinical problems," Durango CO, June 6, 2000.

185. Invited Speaker, 42^nd Annual World Congress - ICA ‘2000 (International College of Angiology). "A new system for cerebrovascular reconstructions - Non-penetrating arcuate-legged clips," Coronado CA, June 30, 2000.

186. Invited Speaker, 5^th Congress of the International Society for Experimental Microsurgery. "A five year study of "sutureless" cerebrovascular reconstructions: Assets and liabilities," Catania, Italy, September 4, 2000.

187. Invited Speaker, 5^th Congress of the International Society for Experimental Microsurgery. "Microvascular free tissue transfer in the presence of coagulation and vessel disorders: Recognition and Solutions," Catania, Italy, September 6, 2000.

188. Invited Speaker, Harvard University. "VCS clip applier workshop and tutorial," Natick MA, September 22, 2000.

189. Invited Speaker, 2000 Annual ClinicalAssembly of Osteopathic Specialists. "The use of non-penetrating clips for dural reconstruction." Boston MA, September 22, 2000.

190. Invited Speaker, 2000 Annual Clinical Assembly of Osteopathic Specialists. "The use of non-penetrating clips in vascular surgery," Boston MA, September 22, 2000.

GRANTS & CONTRACTS AWARDED:

YEAR, AWARD TITLE, AGENCY AMOUNT

1966-1976 Grant General Research Assistance (ACS) $ 14,017

1966-1971 Grant Histochemistry of Brain Tumors (NCI) $ 146,781

1970-1974 Grant Neurosurgery Training (NINDS) $ 142,236

1972-1974 Contract Virus Center Search (NCI) $ 50,598

1976-1978 Grant Pediatric Brain Tumor Study (NCI) $ 46,507

1975-1977 Grant Virus Cancer Research (NCI) $ 4,427

1976-1979 Grant Cell Synchronization in Solid $108,441

Tumors (NCI)

1976-1979 Grant Pain Control in Cancer Patients (NCI) $ 142,354

1974-1976 Grant Chemotherapy of Brain Tumors (VAH) $ 71,999

1977-1980 Grant Immunocytochemistry of Human Brain $ 118,061

Tumors (VAH)

1979-1982 Grant Fibrinolysis and Perineoplastic $ 124,500

Brain Tumor Edema (VAH)

1983-1984 Grant Distribution of $-carboxyaspartic acid $ 10,000

(Asa) and aminomalonic acid

("-carboxyglycine, or Ama) in proteins

(UNM Research Allocations Committee)

1983-1984 Grant Cost-Effectiveness of Neurosurgical $ 10,000

Care in the Native American Indian

Population (UNM Foundation)

1983-1986 Grant Carboxylated Amino Acids in $ 140,000

Experimental Atherosclerosis (VAH)

1984-1986 Grant Anatomic and Physiologic Studies of $ 5,000

Rat Arteries and Veins Anastomosed with a Novel Microclip (UNM Foundation)

1984- Grant Proposal for Gene Study I $ 10,000

(Biochemistry of Brain Tumors)(UNM Research Allocations Committee)

1985- Grant Shiley Valve Calcification Study $ 5,126

(Shiley)

1985- Grant A New Amino Acid and Atherosclerosis $ 5,000

(Fraternal Order of Eagles)

1985 Donation Research Funding (Public Service $ 2,500

Company of New Mexico)

1986- Grant Study of Cranial Shunt Infections and $ 5,750

Malfunctions (Codman, Inc.)

1986-1988 Grant Biologic Mechanism for Bioprosthetic $ 96,908

Implant Calcification (VAH)

1986- Grant Microvascular Clip Development $ 250,000

(Ethicon, Inc.)

1987- Grant A New Amino Acid and Atherosclerosis $ 218,520

(Johnson & Johnson)

1988- Grant Mechanical Properties of Coronary $ 13,333

Artery Anastomoses: Suture vs. Microclip

(Davis & Geck)

1990- Grant Characterization of a Percarboxylated $ 26,801

Epitope in Foam Cells (VAH)

1990- Grant Identification of Peptides Hydrolyzed from Ama-containing protein found on the surface of foam cells (Loma Linda University School of Medicine) $ 5,100

1991- Grant Peripheral Nerve Repair (New Medico Head Injury Systems) (Dr. Kirsch) $ 5,000

1991- Grant Minimal Invasive Surgical Laboratory $ 65,000

(LLUMC)

1991- Grant Minimal Invasive Surgical Laboratory $ 100,000

(USSC)

1993 Donation Microvascular Clip (W.L. Gore Associates, Inc.) & $ 1,000

1993 Donation Cabot Medical Corporation $ 85,000

1993-1994 Consulting United States Surgical Corporation Grant (Donated to Minimal Invasive Lab) $ 100,000

1994 Contract United States Surgical Corporation (Vascular Access Study with clips) $ 45,000

1994 Grant Bio-Vascular, Inc. $ 30,000

1996 Grant United States Surgical $ 91,400

(Dural Repair)

1997 Grant United States Surgical Corporation $ 42,000

(Biochemical, Biophysical, Morphological Properties of Stretched Ligaments)

1998 Grant United States Surgical Corporation $ 35,000

(Femoral Artery Hole Closure Device)

1998 Grant United States Surgical Corporation - Tyco $ 1,500,000

Equipment 500,000

GRAND TOTAL $ 4,387,376

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