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Plasma amino acids
Definition
Plasma amino acids is a screening test done on infants that looks at the amounts of amino acids in the blood. Amino acids are the building blocks for proteins in the body.
See also:
Alternative Names
Amino acids blood testHow the Test is Performed
A blood sample is needed. The area (usually the heel) is cleansed with germ-killing solution, and the skin is punctured with a sharp needle or a lancet. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
The blood sample is sent to a lab. Chromatography is used to determine the amino acids levels in the blood.
How to Prepare for the Test
The baby should not be fed for 4 hours before the test.
See also: Test/procedure preparation - infant
How the Test Will Feel
The needle stick will probably cause the infant to cry.
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the Test is Performed
This test is done to measure the level of amino acids in the blood.
An increased level of a particular amino acid is a strong sign that there is a problem with the body's ability to break down (metabolize) that amino acid.
The test may also be used to look for decreased levels of amino acids in the blood, which may occur with fevers, inadequate nutrition, and certain medical conditions.
Normal Results
- Alanine
- Children: 200 to 450
- Adults: 230 to 510
- Alpha-aminoadipic acid
- Children: not measured
- Adults: not measured
- Alpha-amino-N-butyric acid
- Children: 8 to 37
- Adults: 15 to 41
- Arginine
- Children: 44 to 120
- Adults: 13 to 64
- Asparagine
- Children: 15 to 40
- Adults: 45 to 130
- Aspartic acid
- Children: 0 to 26
- Adults: 0 to 6
- Beta-alanine
- Children: 0 to 49
- Adults: 0 to 29
- Beta-amino-isobutyric acid
- Children: not measured
- Adults: not measured
- Carnosine
- Children: not measured
- Adults: not measured
- Citrulline
- Children: 16 to 32
- Adults: 16 to 55
- Cystine
- Children: 19 to 47
- Adults: 30 to 65
- Glutamic acid
- Children: 32 to 140
- Adults: 18 to 98
- Glutamine
- Children: 420 to 730
- Adults: 390 to 650
- Glycine
- Children: 110 to 240
- Adults: 170 to 330
- Histidine
- Children: 68 to 120
- Adults: 26 to 120
- Hydroxyproline
- Children: 0 to 5
- Adults: not measured
- Isoleucine
- Children: 37 to 140
- Adults: 42 to 100
- Leucine
- Children: 70 to 170
- Adults: 66 to 170
- Lysine
- Children: 120 to 290
- Adults: 150 to 220
- Methionine
- Children: 13 to 30
- Adults: 16 to 30
- 1-methylhistidine
- Children: not measured
- Adults: not measured
- 3-methylhistidine
- Children: 0 to 52
- Adults: 0 to 64
- Ornithine
- Children: 44 to 90
- Adults: 27 to 80
- Phenylalanine
- Children: 26 to 86
- Adults: 41 to 68
- Phosphoserine
- Children: 0 to 12
- Adults: 0 to 12
- Phosphoethanolamine
- Children: 0 to 12
- Adults: 0 to 55
- Proline
- Children: 130 to 290
- Adults: 110 to 360
- Serine
- Children: 93 to 150
- Adults: 56 to 140
- Taurine
- Children: 11 to 120
- Adults: 45 to 130
- Threonine
- Children: 67 to 150
- Adults: 92 to 240
- Tyrosine
- Children: 26 to 110
- Adults: 45 to 74
- Valine
- Children: 160 to 350
- Adults: 150 to 310
Note: all measurements in micro mole per liter (micro mol/L). The normal range of values may vary between different laboratories.
What Abnormal Results Mean
An increase in the total level of amino acids in the blood amino may be due to:
- Eclampsia
- Fructose intolerance
- Ketoacidosis (from diabetes)
- Kidney failure
- Reye syndrome
A decrease in the total level of amino acids in the blood may be due to:
- Adrenal cortical hyperfunction
- Fever
- Hartnup disease
- Huntington's chorea
- Malnutrition
- Nephrotic syndrome
- Phlebotomus fever
- Rheumatoid arthritis
Risks
Risks associated with having blood drawn are slight:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Considerations
Screening infants for increased levels of amino acids can lead to early diagnosis of inborn errors of metabolism. Early treatment for such conditions may prevent complications such as severe mental retardation.
Reviewed By: Daniel R Alexander, MD, Department of Internal Medicine, St. Mary's Hospital, Leonardtown, MD. Review provided by VeriMed Healthcare Network.
