Loma Linda University International Heart Institute (LLUIHI) invests in research to challenge and improve current practices and standards. Through research activities and clinical trials, LLUMC physicians contribute to innovations in cardiology while advancing the health and care of patients worldwide.


With extensive training in clinical and research settings, LLUIHI’s doctors are committed to contributing to the medical field by publishing their studies and findings in scientific journals and books.

Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. Goff DA, Shera DM, Tang S, Lavin NA, Durning SM, Nicolson SC, Montenegro LM, Rome JJ, Gaynor JW, Spray TL, Vossough A, Licht DJ. J Thorac Cardiovasc Surg. 2014 Apr;147(4):1312-8. doi: 10.1016/j.jtcvs.2013.06.021. Epub 2013 Jul 21. PMID: 23879933 [PubMed - in process]

Twin reversed arterial perfusion sequence: a new method of parabiotic twin mass estimation correlated with pump twin compromise. Oliver ER, Coleman BG, Goff DA, Horii SC, Howell LJ, Rychik J, Bebbington MW, Johnson MP. J Ultrasound Med. 2013 Dec;32(12):2115-23. doi: 10.7863/ultra.32.12.2115. PMID: 24277893[PubMed - in process]

Impact of local ablation on interconnected channels within ventricular scar: mechanistic implications for substrate modification. Tung R, Mathuria NS, Nagel R, Mandapati R, Buch EF, Bradfield JS, Vaseghi M, Boyle NG, Shivkumar K. Circ Arrhythm Electrophysiol. 2013 Dec;6(6):1131-8. doi: 10.1161/CIRCEP.113.000867. Epub 2013 Oct 25. PMID: 24162832 [PubMed - indexed for MEDLINE]

Characterization of anatomic ventricular tachycardia isthmus pathology after surgical repair of tetralogy of Fallot. Moore JP, Seki A, Shannon KM, Mandapati R, Tung R, Fishbein MC. Circ Arrhythm Electrophysiol. 2013 Oct;6(5):905-11. doi: 10.1161/CIRCEP.113.000450. Epub 2013 Jul 24. PMID: 23884199 [PubMed - indexed for MEDLINE]

Utility of Preprocedure Checklists in the Congenital Cardiac Catheterization Laboratory. Gordon BM, Lam TS, Bahjri K, Hashmi A, Kuhn MA. Congenit Heart Dis. 2013 Jun 11. doi: 10.1111/chd.12107. [Epub ahead of print] PMID: 23750802 [PubMed - as supplied by publisher]

Sodium bicarbonate causes dose-dependent increases in cerebral blood flow in infants and children with single-ventricle physiology. Buckley EM, Naim MY, Lynch JM, Goff DA, Schwab PJ, Diaz LK, Nicolson SC, Montenegro LM, Lavin NA, Durduran T, Spray TL, Gaynor JW, Putt ME, Yodh AG, Fogel MA, Licht DJ. Pediatr Res. 2013 May;73(5):668-73. doi: 10.1038/pr.2013.25. Epub 2013 Feb 12. PMID: 23403802 [PubMed - indexed for MEDLINE]

Epicardial ablation of ventricular tachycardia: an institutional experience of safety and efficacy. Tung R, Michowitz Y, Yu R, Mathuria N, Vaseghi M, Buch E, Bradfield J, Fujimura O, Gima J, Discepolo W, Mandapati R, Shivkumar K. Heart Rhythm. 2013 Apr;10(4):490-8. doi: 10.1016/j.hrthm.2012.12.013. Epub 2012 Dec 11. PMID: 23246598 [PubMed - indexed for MEDLINE]

Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: effects of surgical duration. Buckley EM, Lynch JM, Goff DA, Schwab PJ, Baker WB, Durduran T, Busch DR, Nicolson SC, Montenegro LM, Naim MY, Xiao R, Spray TL, Yodh AG, Gaynor JW, Licht DJ. J Thorac Cardiovasc Surg. 2013 Jan;145(1):196-203, 205.e1; discussion 203-5. doi: 10.1016/j.jtcvs.2012.09.057. Epub 2012 Oct 27. PMID: 23111021[PubMed - indexed for MEDLINE]

Closure of perimembranous ventricular septal defects with aneurysmal tissue using the Amplazter Duct Occluder I: lessons learned and medium term follow up. El Said HG, Bratincsak A, Gordon BM, Moore JW. Catheter Cardiovasc Interv. 2012 Nov 15;80(6):895-903. doi: 10.1002/ccd.23074. Epub 2012 Aug 20. PMID: 22907908 [PubMed - indexed for MEDLINE]

In silico to in vivo: mutation-specific modeling of arrhythmia risk. Mandapati R, Shivkumar K. J Am Coll Cardiol. 2012 Nov 20;60(21):2192-3. doi: 10.1016/j.jacc.2012.06.060. No abstract available. PMID: 23153845 [PubMed - indexed for MEDLINE]

Catheter ablation of typical atrial flutter in severe pulmonary hypertension. Bradfield J, Shapiro S, Finch W, Tung R, Boyle NG, Buch E, Mathuria N, Mandapati R, Shivkumar K, Bersohn M. J Cardiovasc Electrophysiol. 2012 Nov;23(11):1185-90. doi: 10.1111/j.1540-8167.2012.02387.x. Epub 2012 Jun 26. PMID: 22734591 [PubMed - indexed for MEDLINE]

Blake drains: a novel method of chest drainage after extracardiac fontan operation with autologous pericardium. Gordon BM, Hasaniya NW, Newcombe JB, Daher NS, Jodhka U, Razzouk AJ, Bailey LL. Ann Thorac Surg. 2012 Oct;94(4):1289-94. doi: 10.1016/j.athoracsur.2012.03.077. PMID: 23006686 [PubMed - indexed for MEDLINE]

Ablation of Post Transplant Atrial Flutter and Pseudo-fibrillation Using Magnetic Navigation via a Superior Approach. Tung R, Shivkumar K, Mandapati R. Indian Pacing Electrophysiol J. 2012 Sep;12(5):229-32. Epub 2012 Sep 1. PMID: 23071385 [PubMed]

Early predictors of survival to and after heart transplantation in children with dilated cardiomyopathy. Pietra BA, Kantor PF, Bartlett HL, Chin C, Canter CE, Larsen RL, Edens RE, Colan SD, Towbin JA, Lipshultz SE, Kirklin JK, Naftel DC, Hsu DT. Circulation. 2012 Aug 28;126(9):1079-86. doi: 10.1161/CIRCULATIONAHA.110.011999. Epub 2012 Jul 16. PMID: 22800850 [PubMed - indexed for MEDLINE]

Catheter ablation utilizing remote magnetic navigation: a review of applications and outcomes. Bradfield J, Tung R, Mandapati R, Boyle NG, Shivkumar K. Pacing Clin Electrophysiol. 2012 Aug;35(8):1021-34. doi: 10.1111/j.1540-8159.2012.03382.x. Epub 2012 Apr 17. Review. PMID: 22510160 [PubMed - indexed for MEDLINE]

Functional pace-mapping responses for identification of targets for catheter ablation of scar-mediated ventricular tachycardia. Tung R, Mathuria N, Michowitz Y, Yu R, Buch E, Bradfield J, Mandapati R, Wiener I, Boyle N, Shivkumar K. Circ Arrhythm Electrophysiol. 2012 Apr;5(2):264-72. doi: 10.1161/CIRCEP.111.967976. Epub 2012 Feb 14. PMID: 22333344 [PubMed - indexed for MEDLINE]

Restricting sports for athletes with heart disease: are we saving lives, avoiding lawsuits, or just promoting obesity and sedentary living? Vaseghi M, Ackerman MJ, Mandapati R. Pediatr Cardiol. 2012 Mar;33(3):407-16. doi: 10.1007/s00246-012-0170-6. Epub 2012 Feb 11. Review. PMID: 22327180 [PubMed - indexed for MEDLINE]

The emerging role of cardiac resynchronization therapy in milder heart failure: are we implanting too late for response? Bradfield J, Boyle NG, Mandapati R, Shivkumar K. Curr Heart Fail Rep. 2012 Mar;9(1):51-6. doi: 10.1007/s11897-011-0075-3. Review. PMID: 22135184 [PubMed - indexed for MEDLINE]

Younger gestational age is associated with worse neurodevelopmental outcomes after cardiac surgery in infancy. Goff DA, Luan X, Gerdes M, Bernbaum J, D'Agostino JA, Rychik J, Wernovsky G, Licht DJ, Nicolson SC, Clancy RR, Spray TL, Gaynor JW. J Thorac Cardiovasc Surg. 2012 Mar;143(3):535-42. doi: 10.1016/j.jtcvs.2011.11.029. PMID: 22340027 [PubMed - indexed for MEDLINE]

Wide complex tachycardia with a unique mode of termination: what is the mechanism? Michowitz Y, Mathuria N, Shivkumar K, Mandapati R. Pacing Clin Electrophysiol. 2012 Jan;35(1):97-9. doi: 10.1111/j.1540-8159.2011.03188.x. Epub 2011 Aug 7. No abstract available. PMID: 21819431 [PubMed - indexed for MEDLINE]

The impact of heart failure severity at time of listing for cardiac transplantation on survival in pediatric cardiomyopathy. Larsen RL, Canter CE, Naftel DC, Tressler M, Rosenthal DN, Blume ED, Mahle WT, Yung D, Morrow WR, Orav EJ, Wilkinson JD, Towbin JA, Lipshultz SE. J Heart Lung Transplant. 2011 Jul;30(7):755-60. doi: 10.1016/j.healun.2011.01.718. Epub 2011 Mar 17. PMID: 21419658 [PubMed - indexed for MEDLINE]

Occlusion of Sano conduit with the Amplatzer vascular plug: a reliable method for staged elimination of accessory pulmonary blood flow in single ventricle palliation. Gordon BM, Hashmi A, Kuhn MA. Catheter Cardiovasc Interv. 2010 Nov 1;76(5):705-9. doi: 10.1002/ccd.22585. PMID: 20506346 [PubMed - indexed for MEDLINE]

In situ pericardial extracardiac lateral tunnel Fontan operation: fifteen-year experience. Hasaniya NW, Razzouk AJ, Mulla NF, Larsen RL, Bailey LL. J Thorac Cardiovasc Surg. 2010 Nov;140(5):1076-83. doi: 10.1016/j.jtcvs.2010.07.068. PMID: 20951258 [PubMed - indexed for MEDLINE]

Effects of congenital heart disease on brain development. McQuillen PS, Goff DA, Licht DJ. Prog Pediatr Cardiol. 2010 Aug 1;29(2):79-85. PMID: 20802830 [PubMed]

The autonomic stress of sleep: Sleeping the sleep of death. Mandapati R, Shivkumar K. Heart Rhythm. 2010 Aug;7(8):1075-6. doi: 10.1016/j.hrthm.2010.05.027. Epub 2010 May 25. No abstract available. PMID: 20621623 [PubMed - indexed for MEDLINE]

Treatment of pulmonary vein stenosis with expanded polytetrafluoroethylene covered stents. Gordon BM, Moore JW. Catheter Cardiovasc Interv. 2010 Feb 1;75(2):263-7. doi: 10.1002/ccd.22240. PMID: 20049955 [PubMed - indexed for MEDLINE]

Noninvasive cerebral perfusion imaging in high-risk neonates. Goff DA, Buckley EM, Durduran T, Wang J, Licht DJ. Semin Perinatol. 2010 Feb;34(1):46-56. doi: 10.1053/j.semperi.2009.10.005. Review. PMID: 20109972 [PubMed - indexed for MEDLINE]

Nickel for your thoughts: Survey of the Congenital Cardiovascular Interventional Study Consortium (CCISC) for nickel allergy. Gordon BM, Moore JW. J Invasive Cardiol. 2009 Jul;21(7):326-9. PMID: 19571342 [PubMed - indexed for MEDLINE]