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Frequently Asked Questions About Bile Duct Cancer

Here are some answers to frequently asked questions about bile duct cancer.

Q: What is bile duct cancer?

A:�Bile duct cancer is a rare type of cancer that starts in the bile duct. Like most cancers, it is named for the body part in which it began. If cancer cells are found in other parts of the body, the cancer has spread. This is called metastasis.

Q: What are bile ducts?

A:�The bile duct is a thin tube that extends from the liver to the small intestine. Its purpose is to transport bile. Bile is a fluid that breaks down fats during digestion. The liver secretes bile that is then stored by the gallbladder. The liver and gallbladder are connected to each other and to the small intestine. During meals, the gallbladder releases bile through the bile duct to help with the digestion of food in the intestines. Two areas of the bile duct system are involved in this process:

Illustration of bile ducts and surrounding organs.

  • Intrahepatic bile ducts. These�are a network of many small tubes inside the liver that collect bile from liver cells. These join into right and left larger ducts that then exit the liver.

  • Extrahepatic bile ducts. These are the duct system outside the liver. After exiting the liver, the right and left hepatic ducts join to form the common hepatic duct. The duct draining the gallbladder--called the cystic duct--then merges with the common hepatic duct, which is then called the common bile duct.

Q: What are the risk factors for bile duct cancer?

A:�Doctors are not sure exactly what causes bile duct cancer, but there are some possible risk factors. A history of these problems may increase your risk for bile duct cancer:

  • An autoimmune disease called primary sclerosing cholangitis

  • Chronic ulcerative colitis, which is an inflammatory bowel disease

  • Abnormal bile duct cysts

  • Abnormal connection between the common bile duct and the pancreatic duct

  • Infections from a parasitic worm called a fluke

  • Cirrhosis of any type

Q: What are the symptoms of bile duct cancer?

A:�People with bile duct cancer may not have any symptoms during early stages when the cancer has not spread. People with this type of cancer may have any or all of these symptoms:

  • Jaundice, which causes eyes and skin to turn yellow

  • Pain in the upper right side of the abdomen

  • Itchy skin

  • Dark brown urine

  • Fever or chills

  • Light, clay-colored stool

  • Bloating, loss of appetite, and weight loss

These symptoms may or may not mean a person has bile duct cancer. A person who is having them should see a doctor right away.

Q: How is bile duct cancer diagnosed?

A:�If a person has symptoms of bile duct cancer, the doctor will do a physical exam, obtain blood tests, and order imaging tests, which let the doctor see inside the body.

Q: Should everyone get a second opinion for a diagnosis of bile duct cancer?

A:�Many people with cancer get a second opinion from other doctors. There are many reasons to get a second opinion. Here are some of those reasons:

  • Not feeling comfortable with the treatment decision

  • Being diagnosed with a rare type of cancer

  • Having several options for how to treat the cancer

  • Not being able to see a cancer expert

  • Requirement of some health insurance companies�

  • Family members or significant others who feel like a second opinion is essential for a sound decision�

Q: How can someone get a second opinion?

A:�There are many ways to get a second opinion:

  • Ask a primary care doctor.�He or she may be able to suggest a specialist. This may be a liver MD/hepatologist, surgeon, medical oncologist, or radiation oncologist. Sometimes these doctors work together at cancer centers or hospitals. Never be afraid to ask for a second opinion.

  • Call the National Cancer Institute's Cancer Information Service.�The number is 800-4-CANCER (800-422-6237). They have information about treatment facilities. These include cancer centers and other programs supported by the National Cancer Institute.

  • Seek other options.�Check with a local medical society, a nearby hospital or medical school, or a support group to get names of doctors who can give you a second opinion. Or ask other people who've had cancer for their recommendations.

Q: How is bile duct cancer treated?

A:�Surgery to remove the tumor is the only way to cure this type of cancer. A cure may be possible if the cancer is found early enough. Radiation may be used before or after surgery. It may be used by itself to ease symptoms if surgery is not possible. Chemotherapy may be used, but has not been shown to be as effective in treating this cancer. It may be given either with radiation or by itself in people with bile duct cancer who are not candidates for surgery. Liver transplant may be an option for selected patients.

Q: What's new in bile duct cancer research?

A:�Cancer research should give you hope. Doctors and researchers around the world are looking for and studying ways to prevent, detect, and treat this cancer.

One new type of treatment that may hold promise for bile duct cancer is called photodynamic therapy. It uses a drug called a photosynthesizer and a special type of light to target cancer cells and kill them.

Researchers are exploring new photosynthesizing agents, new light sources, and new ways to combine this therapy with other types of treatment to enhance their effectiveness with fewer side effects.

Researchers are also studying the use of hyperthermia (heating the body to cause a high fever) in combination with certain chemotherapies to treat inoperable extrahepatic bile duct cancers.

Q: What are clinical trials?

A:�Clinical trials are studies of new kinds of cancer treatments. Doctors use clinical trials to learn how well new treatments work and what their side effects are. Promising treatments are ones that work better or have fewer side effects than the current treatments. People who participate in these studies get to use treatments before the�FDA approves them. People who join trials also help researchers learn more about cancer and help future cancer patients.