General Information About Lymphedema
Lymphedema is the build-up of fluid in soft body tissues when the lymph system is damaged or blocked.
The lymph system is a network of lymph vessels, tissues, and organs that carry lymph throughout the body.
The parts of the lymph system that play a direct part in lymphedema include the following:
Lymph: A clear fluid that contains lymphocytes(white blood cells) that fight infectionand the growth of tumors. Lymph also contains plasma, the watery part of the bloodthat carries the blood cells. Lymph vessels: A network of thin tubes that helps lymph flow through the body and returns it to the bloodstream. Lymph nodes: Small, bean-shaped structures that filter lymph and store white blood cells that help fight infection and disease. Lymph nodes are located along the network of lymph vessels found throughout the body. Clusters of lymph nodes are found in the underarm, pelvis, neck, abdomen, and groin.
Lymphedema occurs when lymph is not able to flow through the body the way that it should.
When the lymph system is working as it should, lymph flows through the body and is returned to the bloodstream.
Fluid and plasma leak out of the
capillaries(smallest blood vessels) and flow around body tissues so the cells can take up nutrientsand oxygen.
Some of this fluid goes back into the bloodstream. The rest of the fluid enters the lymph system through tiny lymph vessels. These lymph vessels pick up the lymph and move it toward the heart. The lymph is slowly moved through larger and larger lymph vessels and passes through lymph nodes where waste is filtered from the lymph.
The lymph keeps moving through the lymph system and collects near the neck, then flows into one of two large
The right lymph duct collects lymph from the right arm and the right side of the head and chest.
The left lymph duct collects lymph from both legs, the left arm, and the left side of the head and chest.
These large ducts empty into veins under the
collarbones, which carry the lymph to the heart, where it is returned to the bloodstream.
When part of the lymph system is damaged or blocked, fluid cannot drain from nearby body tissues. Fluid builds up in the tissues and causes swelling.
There are two types of lymphedema.
Lymphedema may be either primary or secondary:
Primary lymphedema is caused by the
abnormaldevelopment of the lymph system. Symptomsmay occur at birth or later in life.
Secondary lymphedema is caused by damage to the lymph system. The lymph system may be damaged or blocked by infection, injury, cancer, removal of lymph nodes,
radiationto the affected area, or scar tissue from radiation therapyor surgery.
This summary is about secondary lymphedema in adults that is caused by cancer or cancer treatment.
Possible signs of lymphedema include swelling of the arms or legs.
Other conditions may cause the same symptoms. A doctor should be consulted if any of the following problems occur:
Swelling of an arm or leg, which may include fingers and toes.
A full or heavy feeling in an arm or leg.
A tight feeling in the skin.
Trouble moving a
jointin the arm or leg.
Thickening of the skin, with or without skin changes such as blisters or
A feeling of tightness when wearing clothing, shoes, bracelets, watches, or rings.
Itching of the legs or toes.
A burning feeling in the legs.
Loss of hair.
Daily activities and the ability to work or enjoy hobbies may be affected by lymphedema.
These symptoms may occur very slowly over time or more quickly if there is an infection or injury to the arm or leg.
Cancer and its treatment are risk factors for lymphedema.
Lymphedema can occur after any cancer or treatment that affects the flow of lymph through the lymph nodes, such as removal of lymph nodes. It may develop within days or many years after treatment. Most lymphedema develops within three years of surgery.
Removal and/or radiation of lymph nodes in the underarm, groin, pelvis, or neck. The risk of lymphedema increases with the number of lymph nodes affected. There is less risk with the removal of only the
sentinel lymph node(the first lymph node to receive lymphatic drainagefrom a tumor).
Slow healing of the skin after surgery.
A tumor that affects or blocks the left lymph duct or lymph nodes or vessels in the neck, chest, underarm, pelvis, or abdomen.
Scar tissue in the lymph ducts under the collarbones, caused by surgery or radiation therapy.
Lymphedema often occurs in
Tests that examine the lymph system are used to diagnose lymphedema.
It is important to make sure there are no other causes of swelling, such as infection or blood clots. The following tests and procedures may be used to
Physical examand history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient?s health habits and past illnesses and treatments will also be taken. Lymphoscintigraphy: A procedure used to make pictures (called scintigrams) of the lymph system to check for blockages or anything else that seems unusual. A radioactivesubstance is injectedunder the skin, between the first and second fingers or toes of each hand or foot. The substance is taken up by the lymph vessels and detected by a scanner. The scanner makes images of the flow of the substance through the lymph system on a computer screen. MRI(magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body. This procedure is also called nuclear magnetic resonance imaging (NMRI).
The swollen arm or leg is usually measured and compared to the other arm or leg. Measurements are taken over time to see how well treatment is working.
A grading system is also used to diagnose and describe lymphedema. Grades 1, 2, 3, and 4 are based on size of the affected limb and how severe the signs and symptoms are.
Stages may be used to describe lymphedema.
Stage I: The limb (arm or leg) is swollen and feels heavy. Pressing on the swollen area leaves a pit (dent). This stage of lymphedema may go away without treatment.
Stage II: The limb is swollen and feels spongy. A condition called tissue
fibrosismay develop and cause the limb to feel hard. Pressing on the swollen area does not leave a pit.
Stage III: This is the most advanced stage. The swollen limb may be very large. Stage III lymphedema rarely occurs in breast cancer patients. Stage III is also called lymphostatic elephantiasis.
Patients can take steps to prevent lymphedema or keep it from getting worse.
Preventive steps include the following:
Tell your health care provider right away if you notice symptoms of lymphedema.
See the General Information section for
Keep skin and nails clean and cared for, to prevent infection.
Use cream or lotion to keep the skin moist.
Treat small cuts or breaks in the skin with an
Avoid needle sticks of any type into the limb (arm or leg) with lymphedema. This includes shots or
Use a thimble for sewing.
Avoid testing bath or cooking water using the limb with lymphedema. There may be less feeling (touch, temperature, pain) in the affected arm or leg, and skin might burn in water that is too hot.
Wear gloves when gardening and cooking.
sunscreenand shoes when outdoors.
Cut toenails straight across. See a
podiatrist(foot doctor) as needed to prevent ingrown nails and infections.
Keep feet clean and dry and wear cotton socks.
Avoid blocking the flow of fluids through the body.
It is important to keep body fluids moving, especially through an affected limb or in areas where lymphedema may develop.
Do not cross legs while sitting.
Change sitting position at least every 30 minutes.
Wear only loose jewelry and clothes without tight bands or elastic.
Do not carry handbags on the arm with lymphedema.
Do not use a
blood pressurecuff on the arm with lymphedema.
Do not use elastic bandages or stockings with tight bands.
Keep blood from pooling in the affected limb.
Keep the limb with lymphedema raised higher than the heart when possible.
Do not swing the limb quickly in circles or let the limb hang down. This makes blood and fluid collect in the lower part of the arm or leg.
Do not apply heat to the limb.
Studies have shown that carefully controlled exercise is safe for patients with lymphedema.
Exercise does not increase the chance that lymphedema will develop in patients who are at risk for lymphedema. In the past, these patients were advised to avoid exercising the affected limb. Studies have now shown that slow, carefully controlled exercise is safe and may even help keep lymphedema from developing. Studies have also shown that, in breast-cancer survivors, upper-body exercise does not increase the risk that lymphedema will develop. (See the Exercise section under Treatment of Lymphedema for more information.)
Treatment of Lymphedema
The goal of treatment is to control the swelling and other problems caused by lymphedema.
Damage to the
Treatment of lymphedema may include the following:
Both light exercise and
Talk with a certified lymphedema therapist before beginning exercise.
Patients who have lymphedema or who are at risk for lymphedema should talk with a certified lymphedema therapist before beginning an exercise routine. (See the Lymphology Association of North America Web site for a list of certified lymphedema therapists in the United States.)
Wear a pressure garment if lymphedema has developed.
Patients who have lymphedema should wear a well-fitting pressure garment during all exercise that uses the affected limb or body part.
When it is not known for sure if a woman has lymphedema, upper-body exercise without a garment may be more helpful than no exercise at all. Patients who do not have lymphedema do not need to wear a pressure garment during exercise.
Breast cancer survivors should begin with light upper-body exercise and increase it slowly.
Some studies with
breast cancer survivorsshow that upper-body exercise is safe in women who have lymphedema or who are at risk for lymphedema. Weight-lifting that is slowly increased may keep lymphedema from getting worse. Exercise should start at a very low level, increase slowly over time, and be overseen by the lymphedema therapist. If exercise is stopped for a week or longer, it should be started again at a low level and increased slowly.
symptoms(such as swelling or heaviness in the limb) change or increase for a week or longer, talk with the lymphedema therapist. It is likely that exercising at a low level and slowly increasing it again over time is better for the affected limb than stopping the exercise completely.
More studies are needed to find out if weight-lifting is safe for cancer survivors with lymphedema in the legs.
Once the lymph fluid is moved out of a swollen limb,
The goal of skin care is to prevent infection and to keep skin from drying and cracking. See skin care tips, in the Managing Lymphedema section.
Compression devices are
In patients who are
Lymphedema is not usually treated with drugs.
Lymphedema caused by cancer is rarely treated with
When done correctly, massage therapy does not cause medical problems. Massage should not be done on any of the following:
wounds, bruises, or areas of broken skin. Tumorsthat can be seen on the skin surface.
deep vein thrombosis( blood clotin a vein).
Sensitive soft tissue where the skin was treated with
When lymphedema is severe and does not get better with treatment, other problems may be the cause.
Sometimes severe lymphedema does not get better with treatment or it develops several years after surgery. If there is no known reason, doctors will try to find out if the problem is something other than the original cancer or cancer treatment, such as another
Current Clinical Trials
Check NCI?s list of cancer clinical trials for U.S. supportive and palliative care trials about lymphedema that are now accepting participants. The list of trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
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Changes to This Summary (08/19/2011)
Changes were made to this summary to match those made to the health professional version.
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