Zhang Neuroscience Research Laboratories News
$1.73 Million R01 Grant from the National Institutes of Health (NIH) is awarded to John Zhang, MD, PhD
A $1.73 million R01 grant from the National Institutes of Health (NIH) was recently awarded to John Zhang, MD, PhD and his team of students, residents, and postdoctoral researchers, for their project entitled “Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury”.
Surgery causes inevitable injury to the normal tissues. For neurosurgeons, this issue is more pronounced due to the fragile nature of brain tissue. This project addresses reducing intraoperative bleeding and post-surgery edema using an unconventional approach. The grant proposal findings show that using small dosages of Crotalus snake venom may boost the endogenous protective response in an experimental neurosurgery procedure. After 3 days of the subcutaneous Crotalus snake venom treatment, in an experimental neurosurgery model, the procedure proved much less bleeding and brain edema were observed after a fronto-lobectomy in rats.
Because millions of surgeries are done each year in this country, if intraoperative bleeding and post-surgery edema can be reduced, this may impact a patients’ recovery, reduce the hospital stay, and decrease the cost of national health care.
The researchers in the Dr. Zhang’s neuroscience laboratory that are involved in the initial planning, writing, and revising of this grant proposal are Miss Cherine Kim, a MD/PhD candidate, Dr. Tim Lekic, a resident in Neurology, Dr. Raval Ronak, a resident in Anesthesiology, and Dr. Devin McBride, a postdoctoral fellow.
Summer Potluck 2014
At the end of July, Zhang Lab hosted a potluck to welcome new lab members and bid farewell to those leaving. French students Julia Legrand, Loic Adam, Jean-Sebastien Louis, Guillaume Oudin, and Corentin Waker finished their internships. Di Chen, Bo Li, and Yue He have neared completion of their studies and will be heading back to China to finish their papers. Paul Krafft will be heading to New Mexico for clinical rotations. We also welcomed Onat and Gokce Akyol, who are anesthesiologists from Turkey. Mert Demirci and Miray Cimsit are visiting research students from Turkey. Cheng Yin is a post-doc joining us from China. Justin and Richard Camara are graduating medical students who enrolled in the PhD program and will be joining our lab. To those leaving, we appreciate your hard-work and contributions to our lab and wish you the best on your future endeavours. To those joining, welcome and we look forward to your accomplishments during your time with us.
Spring 2014 BBQ and Farewell to William Rolland
Dr. Zhang and Dr. Tang hosted lab members to a BBQ at their home and everyone congratulated William Rolland for nearing the end of his PhD program. William Rolland was instrumental in establishing our Germinal Matrix Hemorrhage model and his work played a key role in getting an R01 grant funded for continued GMH research. William Rolland also contibuted towards the PPG grant for establishing the Center for Brain Hemorrhge Research. He managed the lab and trained many researchers over the years on performing stereotaxic rodent surgeries as well as other relevant lab techniques. He will be missed, but we wish him the best on his next steps. Meanwhile, the lab is expanding with new members and added lab space within Risley Hall as plans are put into motion to continue developmet of the Center for Brain Hemorrhage Research.
$7.7 Million NIH PPG Funded to Establish the Center for Brain Hemorrhage Research
The new center will focus on elucidating the neurophysiological mechanisms behind and potential novel therapeutic modalities for hemorragic stroke and traumatic brain injuries. Dr. John Zhang and fellow collaborators, Drs. Jiping Tang, Jerome Badaut, Andre Obenaus, Richard Hartman, and William Pearce will lead the establishment and development of the first brain hemorrhage research center in the US. Congratulations to this group and good luck on carrying out the center's aims!
Dr. Cenk Ayata MD Visits the Lab
Dr. Cenk Ayata visited the lab on Thursday, November 21, 2013 and gave a very intriguing seminar presentation to the basic sciences department about the relationship between migraines, cortical spreading depression, and stroke. Dr. Ayata is a neurologist and physician scientist, with positions as Assistant Professor at Harvard Medical School and as Assistant in Neurology and Neuroscience at Massachusetts General Hospital. His contributions to the neurovascular research field include developing and integrating eloctrophysiological and multimodal optical imaging techniques to explore therapies enhancing perfusion and oxygenation in acute stroke, cortical spreading depression in migraines, and injury depolarization pathophysiology in stroke. Thank you Dr. Ayata for your visit and we wish you the best in your future research efforts.
Neonatal Hypoxic-Ischemia Grant Funded by the American Heart Association
Tim Lekic's grant on intranasal osteopontin administration in the neonatal hypoxic-ischemia model has been funded by the American Heart Association. Tim is one of the first few residents to win a national competition and be awarded an AHA grant. Congratulations to him and Desislava Doycheva, who worked extensively on the grant, for their success. We look forward to executing the aims in their proposed study.
Western Anesthesiology Residents Conference 2013
Congratulations to Tiffany Hadley MD and Ronak Raval MD, who won first and third place respectively at WARC 2013 for best oral presentation. Dr. Hadley's presentation was titled "Anti-neutrophil Antibody Enhances the Neuroprotective Effects of G-CSF by Decreasing Neutrophil Mobilization in Hypoxic Ischemic Neonatal Rat Model" and Dr. Raval's presentation was titled "Decreased surgical bleeding in Sprague Dawley rats pretreated with Crotalus atrox venom".
International Anesthesia Research Society 2013
Congratulations to Arthur Leitzke for winning the Society for Neuroscience in Anesthesiology and Critical Care Award at IARS 2013. His presentation was titled "Isoflurane Post-Treatment Ameliorates Germinal Matrix Hemorrhage-Induced Brain Injury by Activating the Sphingosine Kinase/AKT Pathway in Neonatal Rats".
An NIH RO1 grant titled "Neurovascular Protection for Early Brain Injury after SAH" was submitted in fall of 2012 and recently received a funding score. Congratulations to Prativa Sherchan for her hard work and contributions to this grant! We are excited to continue our work and expand the fields knowledge in SAH injury.
Dr. Marc Simard MD PhD visits the lab
Dr. Marc Simard MD PhD, an accomplished neurosurgeon and clinical researcher from the University of Maryland, visited the lab on Thursday, March 14, 2013. He gave a very insightful seminar presentation titled "The Sur1-Trpm Channel in CNS Injury". The lab enjoyed spending the day with him and is grateful for the knowledge and expertise he shared with us from his work in stroke and traumatic brain injury. We wish him the best in his future studies at the University of Maryland.
On Sunday, March 17, 2013 Dr. Zhang and Dr. Tang opened their home to the lab and hosted a BBQ. We want to congratulate the current members for their hard work and contributions as well as welcome our new members from China, including Yan Peng, Yujie Chen, Yang Zhang, and Junjia Tang.
On Friday, December 14, 2012 the Zhang lab hosted a holiday luncheon. Lab members were given a gift in celebration of the holiday season. We also said good-bye to Sheng Chen, who will be returning to China at the end of December. We thank Sheng for his valuable contributions to the lab and congratulate him on his SAH research. We wish him the best in his future career pursuits. We also wish everyone a happy holidays!
In March 2012, an RO1 NIH grant propsoal on collagenase-induced germinal matrix hemorrhage in neonatal rat pups was resubmitted, reviewed, and received a funding score. Funding for this exciting project will begin in February 2013. Congratulations to William Rolland, Paul Krafft, and Tim Lekic for their significant contributions. We are thrilled to continue the work which they have started and expand the field's knowledge on pre-term germinal matrix hemorrhage injury.
Zhang Lab Potluck
On 8/24/2012, we said good-bye to Dr. Mutsumi Fujii, who will return to Japan with his family. Dr. Fujii has completed his projects on SAH after working with us for over two years. We look forward to his future publications and wish him the best.
BBQ at Dr. Zhang and Dr. Tang's House
On 8/5/2012, Dr. Zhang and Dr. Tang hosted a BBQ for the lab at their beautiful home. Our lab's diversity was reflected in the variety of grill prepared meals contributed by our members. Everyone bonded and enjoyed themselves on this hot, summer afternoon, especially Dr. Zhang and Dr. Tang's dogs. Congratulations to our lab for their hard-work over the summer.
Congratulation Dr. M.S. Charles
Our best wishes to Melissa upon completing her PhD in Microbiology. On 5/27/2012 she presented the results of her projects to the committee in a defense who then accepted her for graduation after spending four years in our lab. Melissa will be completing her degree by starting Medical School. Good luck to her, and many more good news to come.
Dr. Alexander Vahmjanin joins us
We welcome Dr. Vahmajanin, an abdominal surgeon from Russia to Loma Linda University on 4/1/2012. Alexander is now starting his own study in a rat model of Subarachnoid Hemorrhage. We wish him luck !
Zhang Lab Potluck
On January 20, 2012 we said good-bye to three members of Dr. Zhang’s Lab, Drs. Caner, Sun and Soejima. Our colleagues completed their projects and returned to their home countries, where they will continue with their work. We are looking forward to their future publications.
Dr. Ming's Visit
On March 28th, 2012 we welcomed Dr. Mingming Ning at Zhang’s Neuroscience Research Laboratory in Loma Linda University. Dr. Ning, an assistant professor in neurology at Harvard Medical School and Neurologist at Massachusetts General Hospital is well known for her research in brain ischemia and stroke. Dr. Ning met with faculty and graduate students and also gave a seminar on Clinical Proteonomics, exploring neurovascular pathophysiology using a translational approach and discussing alternative treatments for stroke patients. We enjoyed her visit at Loma Linda University and wish her continuing success with her clinical work and research.
Welcome Loma Linda University Medical Students
Arthur Leitzke and Nicole Van Allen have joined our lab, they will be with us until June 2012.
Arthur joined us in December 2011. He is working in our lab for the Anesthesia Department under Dr. Applegate. His interests include the effects of Inhaled Volatile Gases in different animal stroke models. Nicole joined us in 2012. She will be assisting with various research projects and will be writing a review on inhaled volatile gases.
Here is a warm welcome on behalf of everyone in Zhangs' lab!
Zhang Lab Potluck
On December 13, 2011 the Zhang Lab organized a potluck in celebration of Rhonda Souvenir and Qingyi Ma's completion of their doctoral degree. Both of them graduated in 2011.
We bid farewell to Dr. Junhao Yan who is leaving our lab after successful completion of his project.
Our best wishes to all of them.
Dr. Dru Perera Joins us
Dru joined our research lab in 2012. She is a medical doctor from Sri-Lanka and is expected to be here with us for one year developing various experimental therapies. Here's a warm welcome on behalf of everyone in Zhangs' Lab!
Professor Jun Chen visited LLU
We welcomed Professor Jun Chen to Loma Linda University on January 25, 2012. Dr. Jun Chen is a professor of Neurology and Pharmacology at the University of Pittsburgh who specializes in the molecular mechanisms associated with cerebral ischemia, and Parkinson’s disease. His work focuses on determining the role of apoptosis and mitochondrial dysfunction using various in vivo and in vitro disease models. Dr. Chen visited the Zhang Neuroscience research laboratory and met with stuffs and graduate students. We were very fortunate having him presented a lecture to Loma Linda faculty and graduate students on DNA repair and neuro-protection against ischemic neuronal injury.
Associate Professor Xiaoying Wang visited LLU
Faculty and students from LLU welcomed Associate Professor Xiaoying Wang from Harvard University on January 11, 2012. Dr. Wang visited the Zhang Neuroscience Research Lab and changed new and exciting ideas with graduate students and staffs. On January 12, 2012, Dr. Wang delivered a lecture on Neuroprotection and Reperfusion, Targets for Stroke Therapy which was hosted by Professor John Zhang. We would like to thank Dr. Wang for his commendable expertise and sharing his thought on stroke research.
Congratulations to Dr. Anatol ManaenkoDr. Manaenko's collaborative and translational research grant entitled " Effect of endometrial regenerative cells on brain injury after intracerebral hemorrhage" has been funded. The grant award will support this innovative project for the duration of two years. We wish Dr. Manaenko good luck on his endeavors as we anticipate the results of the study.,/p>
Greetings Damon and Jerry
Damon Klebe a graduate from University of California, Berkeley joined the Zhang Neuroscience Research Lab in July 2011 as a research intern.
Jerry Flores, a student from University of California, Riverside joined in September 2011 as a research intern.
We are glad to have them on board.
Zhang Lab Potluck
On July 13, 2011 the Zhang Lab organized a potluck in celebration of Rhonda Souvenir and Qingyi Ma's completion of their doctoral degree. Both of them graduated in 2011.
We bid farewell to Dr. Junhao Yan who is leaving our lab after successful completion of his project.
Our best wishes to all of them.
Welcome Regina, John and Jack
We welcome Miss Regina Peters. Regina is a research student from the University of California (Riverside), she joined the Zhang's Neuroscience Laboratory in June 2011. She is interested in germinal matrix hemorrhage.
Jack Hou, a medical student form Copenhagen (Denmark), joined our lab in June 2011. His research interest is intracerebral hemorrhage.
Dr. John Yoon graduated from Loma Linda University medical school. He is interested in model of neonatal hypoxia/ischemia. John joined the lab in June 2011.
Research members joined the Zhang Lab
We extend our warm welcome to Drs. Wendy Woo and Esther Komanapalli who have joined our lab from the Department of Anesthesiology. They will both be conducting research on surgical brain injury. We wish them all the best with their research projects.
We welcome also Mrs. Desislava Met Doycheva, visiting research student from Trinity College (Dublin, UK)
Congratulation to Dr. Anatol Manaenko
Dr. Manaenko was promoted to Assistant Research Professor
Lab luncheon for departing Zhang lab members
The farewell lunch took place in June 2011 to cerebrate departing lab members including Dr. Kamil Duris, Dr. Jun Mu, Dr. Hank Chen, and Dr. Orhan Altay. Many thanks for your hard and productive work and best wishes to you all!
New Zhang lab members in the summer of 2011
Jack Hou, a student from Copenhagen, joined the Zhang Lab for neuroscience research training. Welcome aboard! Warm welcome is also in order for our new graduate students Regina Peters and John Yoon and for summer research students, Charles Mansell, Jessica Yook, Jerry Flores, Damon Klebe, and Aaron Campbell. Best of luck with your neuroscience projects!
Professor Xuejun Sun joined the Zhang Lab
Professor Xuejun Sun came to us from Shanghai in China. Professor Sun is a professor of Diving Medicine and he is also an adjunct Professor in physiology at LLU. Professor Sun published many papers on hyperbaric oxygen and hydrogen and we expect many contributions from him to this lab.
Good Luck Michel and Colleen
After successful completion of their projects, Drs. Michael Benggon and Colleen Pakkianathan have returned back to their clinical work. We are looking forward to their publications and wish them all the best.
The APC award goes to Dr. Nikan Khatibi
Dr. Nikan Khatibi won APC conference of 2011 with flying colors. He received the first place award and gave a brilliant talk before the prestigious audience. The paper he presented has been accepted for publication in Anesthesia and Analgesia. Congratulations! All Zhang lab members savor Nikan's great accomplishment.
Zhang Lab welcomes Dr. Junhao Yan
Dr. Junhao Yan, an accomplished anatomist and neuroscientist from Beijing arrived at the Zhang Lab in December 2010. His major research field is SAH, with a special focus on the mechanisms of early brain injury and cerebral vasospasm. We certainly hope for great outcomes of Junhao’s research.
New students in the Zhang Lab
Melissa Charles and Cherine Kim are the newest additions to our graduate student body. Melissa started an interdisciplinary project dealing with hypothalamic– pituitary–adrenal axis and neuroprotection in the neonate. Cherine’s work is to test new curative agents for perioperative brain injury. Hopefully, they will follow the steps of our very own Michael Burris who recently presented new fascinating results.
Research fellows joined the Zhang Lab
The Zhang Lab welcomes new anesthesia research fellows in the fall of 2010. Dr. Colleen Pakkianathan is conducting studies of neuroprotection by anesthetic agents. Dr. Gary Shih is researching neuroprotectants for neonatal hypoxia-ischemia. We wish both of them a successful pursuit of research projects in the Zhang Lab.
Dr. Basak Caner, a neurosurgeon from Turkey, has been accepted to the Zhang Lab postdoctoral training program. She is going to study mechanisms of brain injury after subarachnoid hemorrhage and is also interested in tumor biology research.
Zhang Lab Potluck
On July 13, 2010 the Zhang Lab organized a potluck in celebration of the newly arrived & departing lab members. New students Johnathan Chou, Timothy Lee, and Mike Zaki have joined us for eight weeks of summer research. We were also welcoming Dr. Michael Benggon from LLU Anesthesiology Department who wants to do research on surgical brain injury. Welcome aboard!
All members of the Zhang lab were saying goodbyes to French students, Jerome Kammer and Frederic Spagnoli. They both have worked with us for a couple of months and made themselves quite popular around here. Congrats and many thanks for your hard work and dedication!
Drs. Paul Krafft and Jun Mu joined the Zhang Lab in the Spring/Summmer of 2010
Paul Krafft is a medical doctor from Germany. His project's aim is to develop novel experimental therapies for intracerebral hemorrhage. Dr. Mu, a neurologist from China, joined us to study neurogenesis in the focal ischemic model of stroke. We are thrilled to have them work with us!
Welcome, Jerome and Frederic
It has become Zhang lab tradition to admit students from France in the summer. This year we are happy to have Jerome Kammer and Frederic Spagnoli from the University of Nancy. This renowned institution for higher learning is located in the city of Nancy, the Art Nouveau capital of France and home to Stanislas square. Both students will pursue their research interests in investigational drugs and medical bioengineering. We believe they will significantly contribute to the scientific output of our lab.
So Long Tim & Nancy
On May 7th, all lab members and our guest speaker, Dr. Carmichael from UCLA, joined Drs. Zhang and Tang in the conference room for a farewell party in honor of our wonderful students, Timothy Lekic and Nancy Fathali. They both will be graduating soon. Tim and Nancy received many words of appreciation and cordial wishes for their future endeavors.
Everybody at the party enjoyed delicious multinational food.
Dr. Nikan Khatibi receives 1st place trophy at WARC
Having completed his outstanding research in the Zhang Lab, Dr. Khatibi submitted an abstract on the experimental therapies of intracerebral hemorrhage to the Western Anesthesia Resident Conference. He gave an oral presentation and was declared a winner of the conference. Congratulations, Nikan!
Welcome, Drs. Yoshiteru Soejima and Mutsumi Fujii
Two Japanese neurosurgeons joined our research staff. Dr. Yoshiteru Soejima from the University of Occupational and Environmental Health in Fukuoka and Dr. Mutsumi Fujii from Tokyo Medical and Dental University joined the Zhang lab in April for two years of postdoctoral training. Dr. Soejima will study the role of cytokines in cerebral ischemia. Dr. Fujii will pursue novel therapies of subarachnoid hemorrhage in the experimental setting. Good luck to both of you!
This year’s Annual Postgraduate Convention held at LLU honored Dr. Robert Ayer from Neurosurgery Department for his research carried out in the Zhang Lab. Dr. Ayer, who had conducted studies on surgical brain injury, received the first place award in the Research Fellow category.
Mr. Adriel Fajilan was granted Alpha Omega Alpha Carolyn L. Kuchein Student Research Fellowship to support his research on new neuroprotectants in neonatal hypoxia.
This calls for a celebration!
Farewell to Drs. Yu Hasegawa and Yilin Zhou
On March 12, 2010 Zhang lab members went for farewell lunch for departing post-doctoral fellows, Drs. Yu Hasegawa and Yilin Zhou. The event took place at BJ’s restaurant in San Bernardino. Both doctors have been productive and well liked by collaborators. During lunch, the doctors received many warm wishes for their future welfare.
Dr. Manaenko receives the Julian Hoff Award
The award, with a check for $1000, was handed to Dr. Anatol Manaenko at the Third International Conference on Intracerebral Hemorrhage in Palm Springs, California on March 9, 2010. His research presentation, which received this honor, was entitled “Geldanamycin Reduced Brain Injury in Mouse Model of Intracerebral Hemorrhage.” It offered in-depth insight into neuroprotective mechanisms of geldanamycin in the treatment of hemorrhagic brain injury. Congrats from the whole Zhang Lab!
Dr. Hank Chen and Bin Huang joined Zhang Lab in January of 2010
Dr. Chen started his postdoctoral fellowship in neurosciences. He is completing a study in post-treatment neuroprotection in surgical brain injury. He is also pursuing his other research interests, which include cerebral angiopathies, neonatal hypoxia and neuroprotection using nano-medicines.
Bin is a graduate student from China who joined Dr. Zhang's lab to complete training in neuroscience research. He will study molecular mechanisms of ICH-induced brain injury.
We hope that their work will soon come to fruition!
Dr. Raj Ratan visited LLU
Dr. Raj Ratan of Cornell University, who is a renowned expert in the hypoxic signaling pathways, visited LLU and delivered a lecture for the IBGS on January 7, 2010. Dr. Ratan, hosted by Dr. Zhang, visited the Zhang Neuroscience Research Lab and met with students and faculty. This meeting resulted in an exchange of ideas and brought new perspectives for collaboration between the two research groups.